Amidines with a trichloromethyl group exhibit the properties of inotropic agents, which are used as scaffolds in synthesizing aza-hete­rocycles and ligands for complex formation. Functionalized amidines show anticancer, antidiabetic activity, antihypertensive antiparasitic agents. The synthesis new functional derivatives such is definitely an urgent task. introduction alkenyl substituent severa...

Thiosulfonates are characterized by a wide spectrum of biological activity and have effective antimicrobial, antithrombotic, antitumor antiparasitic effects. However, the use synthetic sulfur-containing compounds for therapeutic preventive purposes requires study their effect on protective mechanisms maintaining homeostasis, antioxidant status body in particular. The aim was to estimate lipid p...

Phenolic compounds can be efficiently O-methylated with tetramethylammonium chloride in diglyme or polyethyleneglycol (PEG) at temperatures of 150-160 °C and in the presence of either K2CO3 or NaOH. When applying benzyltrimethylammonium chloride as a reagent, the benzylation and methylation of phenols occurs, with the benzylation product always predominating. With allyl-substituted phenols as s...

In our previous study, we found that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal showed anti-cancer effect, but it showed lack of stability and drug likeness. We have prepared several (E)-2,4-bis(p-hydroxyphenyl)-2-butenal analogues by Heck reaction. We selected two compounds which showed significant inhibitory effect of colon cancer cell growth. Thus, we evaluated the anti-cancer effects and possib...

Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipid- and four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and S-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1,2-dimethylhydrazine (DMH) injection (2...

New N-methylimidazole (N-MeIm) complexes of the {Mo(η(3)-allyl)(CO)2(N-N)} fragment have been prepared, in which the N,N-bidentate chelate ligand is a 2-pyridylimine. The addition of a strong base to the new compounds deprotonates the central CH group of the imidazole ligand and subsequently forms the C-C coupling product that results from the nucleophilic attack to the imine C atom. This react...

The organosilicon pyridine-2-olates 1a–1d (RSi(pyO)3, R = Me (a), Ph (b), Bn (c), Allyl (d); pyO pyridine-2-olate) may serve as tripodal ligands toward CuCl with formation of complexes the type RSi(?2-pyO)3CuCl (2a–2d). In addition, for Allyl, more stable isomer 2d? (?O-pyO)Si(?2-pyO)2(?2-Allyl)CuCl was observed. presence dry air (as a source oxygen), reactions and afforded Cu(II) RSi(?2-pyO)4C...

Kinetic investigations of substituent effects in the thermal rearrangement of bis-vinyl ether substrates are reported. Findings indicate that the influence of the various substituent patterns on the rate of rearrangement in these compounds differs from that documented in the literature for the analogous [3,3]-sigmatropic rearrangement of allyl vinyl ethers. In addition, the thermochemical data ...

The sulfurous acid ester, trans-sulfurous acid allyl ester 3-allylsulfanyl-allyl ester 8, along with two known thiosulfinates was isolated from the aqueous ethanol extract of garlic (Allium sativum). The chemical structure of 8 was determined on the basis of spectroscopic data including high resolution mass and two-dimensional NMR techniques. All of these compounds induced methemoglobin formati...

A common characteristic of alliumiis is the odor which is emitted from injured tissues. Volatile organic sulfur compounds generally are accepted as the principal source of this odor. In addition to the aliphatic disulfides reported to constitute the odor and flavor (2, 3, 4, 6, 8, 10, 13), Bernhard et al. (1) reported the presence of allyl monosulfide and allyl alcohol among, the volatiles prod...