نتایج جستجو برای: alzheimers disease ad
تعداد نتایج: 1553203 فیلتر نتایج به سال:
Purpose: The currently accepted view on the use of MRI in dementing disease is that it has little role to play in the diagnostic process. The hypothesis here is that this assertion is wrong. Materials and Methods: We show here how a reliable and fully automatic image analysis system is feasible which can provide a simple yet powerful analysis of the distribution of cerebrospinal fluid. The tech...
Alzheimer’s disease (AD), the most common neurodegenerative disorder, will not only reduce quality of life severely, but also bring heavy economic burden to the family and society. Slow progress in AD therapies partially due to lack of appropriate animal models. APP/PS1 transgenic mouse, a widely used animal model for AD, can be used in lots of aspects for AD related study, such as neuronal apo...
Background: With increasing proportion of geriatric population, late-life co-morbidities including dementias, heart disease, arthritis and cancers are also steadily. Cognitive impairment, mainly affecting the is condition when a person has trouble remembering, learning new things, concentrating or making decisions that affect their everyday life, often considered precursor to more serious disea...
the role of transforming growth factor (tgf)-β1, interferon (ifn)-γ, interleukin (il)-2, il-3, and il-6 in the pathogenesis of alzheimer's disease (ad) has long been reported in literature. in this case-control study, the concentrations of these cytokines in altered t lymphocytes, as well as serum vitamin b12, have been compared in terms of factors such as, age, the clinical course and the pati...
17 In 2011 the National Institute on Aging and Alzheimer’s Association (NIA-AA) created 18 separate diagnostic recommendations for the preclinical, mild cognitive impairment, and 19 dementia stages of Alzheimers disease. Scientific progress in the interim led to an initiative by 20 the NIA-AA to update and unify the 2011 guidelines. This unifying update is labeled a “research 21 framework”, bec...
Alzheimers disease (AD), the most common form of dementia, causes progressive impairment of cognitive functions of patients. There is thus an urgent need to (1) accurately predict the cognitive performance of the disease, and (2) identify potential MRI (Magnetic Resonance Imaging)-related biomarkers most predictive of the estimation of cognitive outcomes. The main objective of this work is to b...
The accumulation of redox-active metal ions, in particular copper, in amyloid plaques is considered to the cause of the intensive oxidation damage to the brain of patients with Alzheimers disease (AD). Drug candidates based on a bis(8-aminoquinoline) tetradentate ligand are able to efficiently extract Cu(2+) from copper-loaded amyloids (Cu-Aβ). Contrarily, in the presence of a bidentate hydroxy...
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