Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. As the most abundant of essential amino acids (EAAs), BCAAs are not only the substrates for synthesis of nitrogenous compounds, they also serve as signaling mole...

To determine the effect of dietary methionine supplementation on intestinal amino acid/peptide/monocarboxylic acid transporter gene expression, a total of 242 male Cobb-500 broilers were fed from day of hatch to 35 d of age using a basal diet deficient in sulfur amino acids (control), or the control diet supplemented with dl-methionine (dl-Met), l-methionine (l-Met) or methionine analog dl-2-hy...

The gastrointestinal tract (GIT) is a metabolically significant site of sulfur amino acid (SAA) metabolism in the body and metabolises about 20 % of the dietary methionine intake which is mainly transmethylated to homocysteine and trans-sulfurated to cysteine. The GIT accounts for about 25 % of the whole-body transmethylation and trans-sulfuration. In addition, in vivo studies in young pigs ind...