Naphthalimides make up a class of organic molecules characterised by excellent spectroscopic properties due to their extended conjugate system. Furthermore, various asymmetric or symmetric compounds can be obtained from naphthalimides the different functionalization that performed on nitrogen and/or aromatic rings. The introduction wide range substituents in positions allows chemical and regula...

The selective functionalization of peptides containing only natural amino acids is important for the modification of biomolecules. In particular, the installation of an alkyne as a useful handle for bioconjugation is highly attractive, but the use of a carbon linker is usually required. Herein, we report the gold-catalyzed direct alkynylation of tryptophan in peptides using the hypervalent iodi...

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, have been used functionalization biomolecules. Herein, we report recent advances up to June 2021 peptide protein modification using hypervalent reagents. Their use as transfer or oxidizing is discuss...

A two-step protocol allowing the C?H amination of cyclic ethers with iminoiodinanes, followed by reduction resulting intermediate has been developed for preparation amino alcohols. The initial functionalization is accelerated visible light, improving reactivity compared to thermal process performed in dark. effect different substituents on photochemical iminoiodinanes studied both experimentall...

We report the asymmetric synthesis of di-3-pentyl (3S,alphaS,7E)-3-N-benzyl-N-alpha-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce delta-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (PNA) formation With this aim, thymine-pentanoic acid 15 and some of its ester derivatives were obtained, their reactivity was studied and th...

In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWCNT–COOH) by 1-Amino-2-naphthol-4-sulfonic acid (ANSA). The functionalized MWCNTs exhibited good aqueous solubility due to the presence of the –OH and – SO3H groups of ANSA. The antimicrobial activity of the MWCNT–COOH as well as its functionalized multiwall nanotube MWCNT-CO-2-(1-amino...

Enzyme modified electrodes were fabricated with poly(aniline-co-maminophenol). Electrochemical polymerization of aniline and m-aminophenol was performed to get the film of copolymer on the surface of gold electrode. Modified electrodes were fabricated by two methods, physical entrapment and covalent cross-linking. In one of the method, gold nanoparticles were loaded into the copolymer film and ...

A series of pseudodipeptide-based chiral 1,3,4,5-tetrasubstituted-2-oxopiperazines has been designed and synthesized as potential PAR1 antagonists. These highly functionalized piperazines were synthesized from aromatic and basic amino acid derived Ψ[CH(CN)NH]pseudodipeptides through a four step pathway that involves reduction of the cyano group to build the 2-oxopiperazine ring, followed by sel...

Difunctionalization of alkenes has become a powerful tool for quickly increasing molecular complexity in synthesis. Despite significant progress in the area of alkene difunctionalization involving the incorporation of a nitrogen atom across the C-C double bonds, approaches for the direct 1,2-carboamination of alkenes to produce linear N-containing molecules are scarce and remain a formidable ch...