According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...

Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...

Sulphanilamide inhibition of the growth of certain yeasts and yeastlike organisms was overcome in a non-competitive manner by methionine, adenine and histidine, which are therefore regarded as end-products of enzyme systems for which p-aminobenzoic acid is essential. The methionine system was the most sensitive to sulphanilamide, followed in order by those of adenine and histidine. In the prese...

A basis for understanding the mode of action of sulfonamide drugs in terms of the WoodsFildes theory of antagonism (Woods, 1940; Fildes, 1940) was provided by the elucidation of the structure of folic acid (Stokstad et al., 1946; Angier et al., 1946; Mowat et al., 1948). Since folic acid contains a p-aminobenzoic acid moiety, it was postulated that the structurally similar sulfonamides compete ...

To identify steps in fungal intermediary metabolism required by Aspergillus spp. during invasive pulmonary aspergillosis, we have developed murine models involving Aspergillus nidulans as the inoculum. The advantages of using A. nidulans over Aspergillus fumigatus or Aspergillus flavus, which are the most common agents of clinical disease, are the well-understood genetics of A. nidulans and a l...

In the presented study, the HPLC method was used for the determination of impurities (p-aminobenzoic acid and p-aminobenzoyl-L-glutamic acid) in single-component pharmaceutical products containing folic acid. The determination was performed using a spectrophotometric detector at lambda = 269 nm wavelength.

In two previous reports, it was shown that cocarboxylase and p-aminobenzoic acid counteract the inhibitory effect of sulfathiazole on yeast and bacterial carboxylases. Whereas cocarboxylase brings about this effect without exercising any inhibitory action on carboxylase, p-aminobenzoic acid exercises the antagonistic action to sulfathiazole while maintaining a certain degree of inhibitory effec...

Nowadays, 2-ethylhexyl 4-(N,N-dimethylamino)benzoate (EDP) is one of the most widely used UV filters in sunscreen cosmetics and other cosmetic products. However, undesirable processes such as percutaneous absorption and biological activity have been attributed to this compound. The in vitro metabolism of EDP was elucidated in the present work. First of all, the phase I biotransformation was stu...