Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in central nervous system, and its application in drugs and functional foods has attracted great attention. To enhance production of γ-aminobutyric acid, Lactobacillus rhamnosus YS9, a strain isolated from Chinese traditional fermented food pickled vegetable, was grown under submerged fermentation. Its cultivation conditions were...

Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Beh9et's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis.

Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning plasticity. What is currently unknown how this knowledge translates to real-life complex cognitive abilities that emerge slowly link between these neurotransmitters human plasticity shaped by development. While some have suggested a generic GABA plasticity, others hypothesized their involvemen...

Cerebrospinal fluid gamma-aminobutyric acid (CSF-GABA) was analysed by radioreceptor assay in 16 normal controls and 84 patients with various neurological and psychiatric diseases. In patients with spinocerebellar degeneration, neuro-Behçet's syndrome and Parkinson's disease, CSF-GABA levels were decreased. On the other hand, increased CSF-GABA levels were detected in patients with meningitis.

Watercore is a physiological disorder which often occurs in Rosaceae fruits, and it causes hypoxia stress, promoting fruit decay. γ-aminobutyric acid (GABA) was reported as being involved different abiotic stresses, glutamate decarboxylase (GAD) the key enzyme of GABA synthesis plants. Our previous transcriptome analysis found that PpGAD2 significantly induced watercore fruit; however, mechanis...

Infection with SARS-CoV-2, the causative agent of COVID-19 pandemic, originated in China and quickly spread across globe. Despite tremendous economic healthcare devastation, research on this virus has contributed to a better understanding numerous molecular pathways, including those involving γ-aminobutyric acid (GABA), that will positively impact medical science, neuropsychiatry, post-pandemic...

γ-Aminobutyric acid (GABA) is an inhibitory neurotransmitter having anti-anxiety, stress-reducing and sleep-enhancing effects. The blood GABA concentration has the potential to become a diagnostic index for depression schizophrenia. In this study, we developed method quantification of in human serum by liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) combine...

The activities of 4-aminobutyric-2-oxoglutaric acid transaminase (GABA-T) and succinate semialdehyde dehydrogenase (SSADH) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (CCK-X)and/or caerulein (CLN). GABA transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of GAB A-T, succinate semiald...

Malus baccata (L.) Borkh. is one of the most widely used rootstocks in apple-producing region Northern China. However, early growing season, apple roots are often subjected to suboptimal low root-zone temperatures. The regulatory effects exogenous γ-aminobutyric acid (GABA) on both shunt (GABA shunt) and respiratory activity under temperatures remain unknown. To explore physiological basis for ...