BACKGROUND Formation of advanced glycation end-products (AGEs) has been implicated in the development of diabetic complications. As well as causing changes in structural proteins, AGEs may also alter gene expression of growth factors in vitro. The insulin-like growth factor (IGF) system, including IGF-I and modulatory IGF binding proteins (IGFBPs), is dysregulated during the development of diab...

The structures of the first two complexes with bidentate coordination aminoguanidine Schiff base, i.e., 2-acetylpyridine-aminoguanidine (L), are reported. complex formula [Cd2Cl6(HL)2] (1) was obtained in reaction warm aqueous solutions chloride salts Cd(II), Zn(II) and ligand, while cadmium bromide ligand presence deprotonating agent as well ammonium thiocyanate resulted formation which base h...

introduction: several studies have indicated that late treatment of aminoguanidine (ag) reduces cerebral ischemic injuries in animal models. however, the effects of early treatment of ag on cerebral ischemic damage are not well understood. this study was designed to evaluate effect of early treatment of ag on cortex and striatum injuries as well as neurological dysfunctions in transient model o...

Advanced glycation end products (AGEs) play important roles in the development of ocular complications in diabetes mellitus. Spontaneously Diabetic Torii (SDT) rats have marked hyperglycemia and severe ocular complications. We evaluated the effect of anti-AGE agents, aminoguanidine and pyridoxamine, and an antioxidant, probucol, on the development of diabetic retinopathy (DR) and cataract in SD...

PURPOSE Gastric mucosa subjected to repeated brief episodes of ischemia exhibits an increased resistance to damage caused by a subsequent prolonged ischemic insult and this is called gastric preconditioning. In this study, L-NNA, a non-selective NO-synthase inhibitor, and aminoguanidine, a relative inhibitor of inducible NO-synthase (iNOS), were applied prior to short ischemia (occlusion of cel...

OBJECTIVES To determine whether alterations of endogenous asymmetric dimethylarginine (ADMA) concentration and dimethylarginine dimethylaminohydrolase (DDAH) activity are involved in endothelial dysfunction induced by glycosylated bovine serum albumin (GBSA) in rats and effects of aminoguanidine on them. METHODS Endothelium-dependent relaxation of aortic rings from Sprague-Dawley rats after t...

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...