Cyclosporin A (CsA) is a P-glycoprotein (P-gp) inhibitor clinically used as an immunosuppressant. Itraconazole (ITZ) functions as an inhibitor of both the P-gp and CYP3A and is used as a fungistatic/fungicidal agent in human and veterinary medicine. The present studies were designed to investigate the effects of CsA and ITZ on 1) intestinal permeability of amlodipine (a calcium channel blocker ...

OBJECTIVE To compare adherence with statin therapy in patients switching to single-pill amlodipine besylate/atorvastatin calcium with patients adding a separate statin to their amlodipine regimen. METHODS We identified hypertensive patients prescribed amlodipine who switched to amlodipine/atorvastatin (switch) or added a statin to their amlodipine regimen (add-on) from July 2004 to June 2007....

Background: The development of newer classes of antiepileptic drugs has created several opportunities for the treatment of epilepsy. Aims & Objective: The present study was designed to assess the effect of amlodipine on the antiepileptic action of lamotrigine, gabapentin and topiramate in the mouse maximal electroshock-induced seizure model. Materials and Methods: 300 Adult male mice were divid...

The beta-blocker atenolol is less effective than angiotensin-receptor blockers and calcium-channel blockers for reducing central blood pressure (BP). The trial was designed to determine whether the advantages of angiotensin-receptor blockers over atenolol remained significant when both were combined with the calcium-channel blocker amlodipine. A prospective, randomized, blinded endpoint (PROBE ...

a series of 1,4-dihydropyridine calcium channel blockers bearing 1-(4-x -benzyl)-5-imidazolyl substituent at 4 position (5a-e) (x=h, f) were synthesized and tested for antihypertensive activity in desoxycorticosterone acetate (doca)-induced hypertension in rats. amlodipine was used as the standard dihydropyridine. all compounds tested showed lower antihypertensive activity than that of amlodipi...

Objective : analyzing the acquisition and monthly costs for patients on modern fixed-dose antihypertensive combinations in three regions of Far Eastern Federal District. Material methods . Intra-group analysis retail drugs 2019 drugstores Khabarovsk Region, Sakhalin Amur Region (n=100) was carried out. The calculation cost therapy performed total sales indicators were identified. Statistical an...

BACKGROUND Black hypertensive patients are more resistant to angiotensin-converting enzyme (ACE) inhibitor monotherapy than White patients. This resistance can be overcome with the combination of ACE inhibitors with diuretics or calcium-channel blockers (CCBs). OBJECTIVES The objective of this clinical investigation was to evaluate the antihypertensive effectiveness of monotherapy with the AC...

A very rare side-effect of amlodipine is dysguesia. A review of the literature produced only one case. We report a case about a female with essential hypertension on drug treatment with amlodipine developed loss of taste sensation. Condition moderately improved on stoppage of the drug for 25 days. We conclude that amlodipine can cause dysguesia. Here, we describe the clinical presentation and r...

Neurology. 2017 Jul 18;89(3):e20. doi: 10.1212/WNL.0000000000004116. Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. Uniyal R(1), Paliwal VK(2), Kumar N(2), Malhotra HS(2), Garg RK(2), Neyaz Z(2). Author information: (1)From the Department of . Find patient medical information for Amlodipine Oral on WebMD including its uses, side effec...

The adsorption processes of amlodipine onto hydrophilic carbon nanoparticles (Emperor 2000TM) are investigated. The significant increase in voltammetric responses for pre-adsorbed amlodipine compared with those for solution confirms high affinity of amlodipine to carbon nanoparticles (possibly due to π-π stacking interaction between aromatic rings of amlodipine and surface-sulfonated carbon nan...