human serum albumin (hsa) is the most abundant plasma protein in the human body. hsa plays an important role in drug transport and metabolism. this protein has a high affinity to a very wide range of materials, including metals such as cu2+ and zn2+, fatty acids, amino acids and metabolites such as bilirubin and many drug compounds. in this study, we investigated the effects of co-amoxiclav, as...

Abstract Post-operative meningitis is a rare but potentially fatal complication of endoscopic endonasal skull base surgery. As approaches to the are clean-contaminated procedures, peri-operative antibiotics routinely used. We sought analyse safety and efficacy single agent, dose protocol in cases anterior Database all skull-base procedures performed ENT Department at Leeds General Infirmary bet...

background and objectives: e. coli and klebsiella spp. are recognized as most prevalent bacteria causing urinary tract infection (uti), the most common bacterial infection. decreasing of antimicrobial susceptibility in urinary pathogens has made difficulty in treatment of uti. the aim of this study was to determine antibiotic susceptibility of e. coli and klebsiella spp. isolated from urine of ...

OBJECTIVES The objectives of this study were to determine antimicrobial resistance and to identify phage types and class 1 integrons among non-typhoidal Salmonella isolates from 24 pig farms in North Carolina collected between 1997 and 2000. METHODS A total of 1314 isolates of 30 serotypes from pig faecal samples were collected and analysed over a 3 year period. The isolates were characterize...

OBJECTIVES To compare the antimicrobial susceptibility of Prevotella spp. isolated from cystic fibrosis (CF) and non-CF patients and analyse the impact of antibiotic prescribing in the preceding year on resistance amongst CF isolates. METHODS The susceptibility of 80 CF Prevotella isolates to 12 antibiotics was compared with that of 50 Prevotella isolates from invasive infections in people wh...

Adverse events and laboratory abnormalities were monitored over 35 days after the commencement of treatment in 45 open studies conducted in Europe, South America, Africa and Asia. These studies were to assess the clinical efficacies of azithromycin and comparator antimicrobial agents in the treatment of paediatric acute bacterial infections. Children (6 months-16 years of age) had been treated ...

Insusceptibility levels of cefaclor and other commonly prescribed antibiotics were determined for 489 consecutive hospital and community-associated urinary tract isolates of Escherichia coli from the Nottingham area of the UK. Significant resistance (MIC of > or = 8 mg/L) to cefaclor was found to be uncommon in the UK, with insusceptibility percentages as low as 1.5% and 1.4% amongst hospital a...

OBJECTIVES We tested a previously published model for the analysis of the temporal relationship between antibiotic use and the incidence of Clostridium difficile infection in a hospital with stable incidence of infection at >1 case per 1000 admissions per month. METHODS The study period was from April 2004 to June 2008 and used data from Infection Control and Hospital Pharmacy. We first descr...