Who gains from more information on the quality of pharmaceutical drugs? Are there incentives for voluntary post-approval clinical trials among pharmaceutical companies? Contrary to popular belief, this paper shows that it is not in the consumer interest that clinical evidence establishing the relative e¤ectiveness within a class of drugs are produced. Pharmaceutical companies, on the other hand...

BACKGROUND No studies have compared the 2-factor structures of Wong's and Post's versions of the short-form Stroke-Specific Quality of Life (i.e., 12-item SSQOL) scale. This study compared the construct validity of 2 short-forms of the 12-item-SSQOL (not the 12-domain-SSQOL). METHODS Data were obtained from a previous validation study of the original 49-item SSQOL in 263 patients. Construct v...

Vibrotactile feedback (VTF) has been shown to improve balance performance in healthy people and people with vestibular disorders in a single-task experimental condition. It is unclear how age-related changes in balance affect the ability to use VTF and if there are different attentional requirements for old and young adults when using VTF. Twenty younger and 20 older subjects participated in th...

A modified version of the nonlinear iterative Chahine algorithm is presented and applied to the inversion of spectral extinction data for particle sizing. Simulated data were generated in a λ range of 0.2-2 µm,and particle-size distributions were recovered with radii in the range of 0.14-1.4 µm. Our results show that distributions and sample concentrations can be recovered to a high degree of a...

Corruption by the politically connected is often blamed for economic ills, particularly in less developed economies. Using a loan-level data set of more than 90,000 …rms that represents the universe of corporate lending in Pakistan between 1996 and 2002, we investigate rents to politically connected …rms in banking. Classifying a …rm as “political”if its director participates in an election, we...

The literature on relational incentive contracts suggests that rms may be able to condition payments to employees on information that is not available to those outside the rm. Given this, market participants may use the magnitude of such payments to infer the non-public information, which then may give rms a reason to choose wage payments strategically. We combine the literatures on relational ...

INTRODUCTION Helicopter overland navigation is a cognitively complex task that requires continuous monitoring of system and environmental parameters and many hours of training to master. This study investigated the effect of expertise on pilots' gaze measurements, navigation accuracy, and subjective assessment of their navigation accuracy in overland navigation on easy and difficult routes. M...

Blue fluorescent protein (BFP) is a mutant of green fluorescent protein (GFP), where the chromophore has been modified to shift the emitted fluorescence into the blue spectral region. In this study, MD calculations were performed with the GROMACS simulation package and AMBER force field to investigate the dependence of BFPs physicochemical properties on temperature and applied pressure. The MD ...

Strength, or maximum joint torque, is a fundamental factor governing human movement, and is regularly assessed for clinical and rehabilitative purposes as well as for research into human performance. This study aimed to identify the most appropriate protocol for fitting a maximum voluntary torque function to experimental joint torque data. Three participants performed maximum isometric and conc...

This article is an empirical evaluation of the choice of fixed cutoff points in assessing the root mean square error of approximation (RMSEA) test statistic as a measure of goodness-of-fit in Structural Equation Models. Using simulation data, the authors first examine whether there is any empirical evidence for the use of a universal cutoff, and then compare the practice of using the point esti...