نتایج جستجو برای: amyloid disaggregation
تعداد نتایج: 39890 فیلتر نتایج به سال:
The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2. Depletion of RuvbL1 or RuvbL2 suppressed aggresome formation and caused buildup of multiple cytoplasmic aggregates. Similarly, downregulation of RuvbL or...
In this paper a novel approach for energy disaggregation is introduced that identifies additive sub-components of the power signal in an unsupervised way from high-frequency measurements of current. In a subsequent step, these sub-components are combined to create appliance power traces. Once the subcomponents that constitute an appliance are identified, energy disaggregation can be viewed as n...
We study an aggregation-disaggregation model which is relevant to biological processes such as the growth of senile plaques in Alzheimer disease. In this model, during the aggregation each deposited particle has a probability of producing a new particle in its vicinity, while during disaggregation the particles are anihilated randomly. The model is held in a dynamic equilibrium by a feedback me...
Over the past few years, dozens of new techniques have been proposed for more accurate energy disaggregation, but the jury is still out on whether these techniques can actually save energy and, if so, whether higher accuracy translates into higher energy savings. In this paper, we explore both of these questions. First, we develop new techniques that use disaggregated power data to provide acti...
Data disaggregation (or downscaling) is becoming a recognized modeling framework to improve the spatial resolution of available surface soil moisture satellite products. However, depending on the quality of the scale change modeling and on the uncertainty in its input data, disaggregation may improve or degrade soil moisture information at high resolution. Hence, defining a relevant metric for ...
Business planning as well as analytics on top of large-scale database systems is valuable to decision makers, but planning operations known and implemented so far are very basic. In this paper we propose a new planning operation called interval disaggregate, which goes as follows. Suppose that the planner, typically the management of a company, plans sales revenues of its products in the curren...
Rain gauge stations that measure fine scale rainfall are mainly limited in number or in the length of the recorded data. Therefore, temporal disaggregation models have been considered because of their ability in generating fine scale data from coarse scale measurements of rainfall. In this study, microcanonical cascade model, which is based on the scaling properties of rainfall and consta...
More than twenty types of proteins can adopt misfolded conformations, which can co-aggregate into amyloid fibrils, and are related to pathologies such as Alzheimer’s disease. This article surveys mathematical models for aggregation chain reactions, and discuss the ability to use them to understand amyloid distributions. Numerous reactions have been proposed to play a role in their aggregation k...
Energy disaggregation is the task of taking a whole-home energy signal and separating it into its component appliances. Studies have shown that having devicelevel energy information can cause users to conserve significant amounts of energy, but current electricity meters only report whole-home data. Thus, developing algorithmic methods for disaggregation presents a key technical challenge in th...
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