نتایج جستجو برای: amyloid precursor protein processing

تعداد نتایج: 1764108  

2008
Gopal Thinakaran Edward H. Koo

Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid -protein (A ), the 38–43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identificatio...

Journal: :Journal of Biological Chemistry 1996

Journal: :Journal of Biological Chemistry 2012

2009
Raluca Stefanescu Radu Stefanescu Michael Przybylski Sylvie Rebuffat Michael Ehrmann Marilena Manea Catalina Damoc Iuliana Susnea Alina Petre Suzanne Becker Madalina Maftei Adrian Moise

It is not the possession of truth, but the success which attends the seeking after it, that enriches the seeker and brings happiness to him. Paraschiv and Ute Schad for all the help they gave me, Reinhold Weber for the organization and expert group leading in the Swiss Alps. Livia and Ioana for their support and the wonderful time spent together. Last but not least I wish to thank and to expres...

Journal: :The EMBO journal 2005
Constanze Reinhard Sébastien S Hébert Bart De Strooper

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

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