PennFS, a Windows 8 Store Application, aims to visualize and simplify the user experience of file management by implementing an alternative file system that is better indexed and organized through relational database. The traditional hierarchical file system has several limitations; especially, when files share multiple relational properties, one file may relate to multiple folders, and the pri...

Gastrointestinal stromal tumours (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the receptor tyrosine kinase KIT are present in most GIST. KIT K642E was originally identified in sporadic GIST and later found in the germ line of a familial GIST cohort. A mouse model harbouring a germline Kit K641E mutant was created to model fa...

In order to overcome many limitations of immunoassays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has the potential to find its place in the clinical laboratory medicine for quantification of steroid hormones. A prerequisite for the application of a new analytical procedure in clinical diagnostics is standardization to minimize analytical intra- and interlabora...

The production process of an active pharmaceutical ingredient (API) by fermentation in an industrial environment was analysed using process analytical technologies. The Food and Drug Administration’s (FDA) process analytical technology (PAT) initiative is intended to be a collaborative effort with industry to promote the integration of new manufacturing technologies into pharmaceutical producti...

-Vertical partitioning is a design technique for reducing the number of disk accesses to execute a given set of queries by minimizing the number of irrelevant instance variables accessed. This is accomplished by grouping the frequently accessed instance variables as vertical class fragments. The complexity of object-oriented database models due to subclass hierarchy and class composition hierar...

OBJECTIVE Fungal urinary tract infections due to Candida have increased significantly in recent years. Our research objective was to study Candida species in urine samples of patients with urinary tract infections (UTIs) associated with obstructive uropathy and to investigate the virulence factors of the isolated Candida. METHODS Patients were divided into two groups: Group I (cases): 50 pati...

Abstract Background Patients with prostate enlargement have an increased risk of recurrent urinary tract infections. This study determined the resistance profile bacteria causing infection (UTI) and magnitude multidrug-resistant (MDR) among patients symptomatic in a tertiary hospital Dar es Salaam. Methods cross-sectional was conducted at Muhimbili National Hospital between August 2021 January ...

Background: Bloodstream infection (BSI) contributes to a substantial proportion of mortality in sub-Saharan Africa and is marked by the presence bacterial and/or fungal microorganisms blood. Because BSI can be life threatening, it requires timely, reliable accurate diagnosis. This study retrospectively analyzed data identified pathogens compared performance different...