If a posterior tooth has been lost and is not restored immediately, the patient may subsequently experience a variety of problems. The adjacent teeth tend to tilt and rotate, and the opposing tooth may overerupt. Available options to restore occlusion include elective root canal treatment with invasive tooth reduction, surgical impaction or orthodontic therapy requiring extraoral headgear or fu...

Tumor growth is characterized by anchorage independence and the loss of contact inhibition. Previously, we showed that either a red fluorescent protein (DsRed)-tagged N-cadherin or E-cadherin cytoplasmic domain (DNCT or DECT) could function as a dominant negative inhibitor by blocking the cell surface localization of endogenous E-cadherin and inducing cell dissociation. Here, we show that expre...

ment can be particularly challenging in adult patients. Although many appliances have been proposed for maxillary molar distalization in such cases,1,2 they generally require some degree of patient compliance, and their de sign causes anchorage loss due to the incorporation of occlusal rests or bands on the premolars. The introduction of skeletal anchorage has radically changed orthodontists’ a...

OBJECTIVE New vessel formation is a dynamic process of attachment, detachment, and reattachment of endothelial cells (ECs) and endothelial progenitor cells (EPCs) with each other and with the extracellular matrix (ECM). Integrin-linked kinase (ILK) plays a pivotal role in ECM-mediated signaling. Therefore, we investigated the role of ILK in ECs and EPCs during neovascularization. METHODS AND ...

The aim of this retrospective study was to determine differences between the outcomes of treatment using implant anchorage compared with straight-pull headgear and intermaxillary elastics in bimaxillary protrusion patients. The lateral cephalograms of 28 adult orthodontic patients (3 males and 25 females; age, 24.9 ± 5.0 years) who had an Angle Class I malocclusion with bimaxillary protrusion w...

Twenty-one anchorage-independent subclones and ten subclones with reduced serum requirements were isolated as single-step mutants spontaneously or after ethylmethanesulfonate or A/-methyl-/V'-nitro-/V-nitrosoguanidine mutagenesis of CHEF/18 diploid Chinese hamster embryo fibroblasts. An chorage-independent mutants retain the high serum require ment and nontransformed morphology typical of CHEF/...

trusion often involves the extraction of four first premolars.1 Since these patients often have Class I molar relationships, the objective is usually to reduce the lip protrusion and correct the incisor inclinations with the least amount of anchorage loss. Although headgear has historically been the standard for maximum anchorage,2,3 its intermittent force application and requirement for patien...

JCO/MAY 2003 C II nonextraction treatment involving headgear and Class II elastics often requires exceptional patient cooperation. As a result, more and more clinicians are prescribing “noncompliance” molar distalization appliances. These appliances have some negative side effects, however, including a significant loss of anchorage that can manifest itself in mesially tipped bicuspids, anterior...

with the growing population and density in metropolitan areas, higher tendency to live in high-rise buildings, and increasing demand for parking lots, it seems necessary to excavate soil to construct underground spaces. during excavation work, as the height of the wall increases, special care should be taken to the wall stabilization to avoid any consequent damage including extensive property d...

Anchorage-independent proliferation is a hallmark of oncogenic transformation and is thought to be conducive to proliferation of cancer cells away from their site of origin. We have previously reported that primary Schwann cells expressing the SV40 Large T antigen (LT) are not fully transformed in that they maintain a strict requirement for attachment, requiring a further genetic change, such a...