Blood doping is an illegal and unfair way of enhancing athletic performance by increasing the oxygen carrying capacity of the blood. Currently used methods usually involve stimulation of erythropoiesis. Gene therapy targeting the hypoxia inducible factor pathway may be an attractive alternative to traditional blood doping techniques. Hypoxia activates a large number of genes with essential role...

The discovery (Smith, 1948; Rickes, Brink, Koniuszy, Wood & Folkers, 1948) that vitamin B,, contains cobalt immediately suggested that it might be possible to label the molecule with radioactive cobalt. A radioactive form of the vitamin would be invaluable for many biochemical investigations. However, as was rather to be anticipated from earlier experiments (Flagg, 1941; McCallum & Hoshowsky, 1...

Cobalt oxide (Co3O4) nanoparticleshave been synthesized by hydrothermal method using mixture of cobalt(II)chloride, Triton X-100 and KOH in an autoclave at 180 °C for 6 h followed by heating at 400 ºC for 3 h in air. The product have been characterized by Fourier transform infrared (FT-IR), UV-Vis spectroscopy, powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission ...

The effect of priming on physiological and biochemical traits French bean (Phaseolus vulgaris) under cobalt chloride stress

Stevia rebaudiana Bert. is a medicinal plant with anti-oxidant, antimicrobial, antifungal and antiviral drug properties which contains two valuable secondary metabolites, stevioside and rebadioside A, with very high sweetness capacity. In this research hairy roots were produced from S. rebaudiana leaf disks using two strains of 15834 and A4 A. rhizogenes. Then, the best hairy root line...

PURPOSE Hypoxia is a critical pathological factor in a variety of retinal diseases, including age-related macular degeneration. It upregulates angiogenic growth factors and promotes neovascularization. Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SIRT1). Activated SIRT1 signals hypoxia inducible factor (HIF)-2α, which transactivates vascular end...

The electrochemical reduction of allyl chloride is strongly catalyzed in the presence of cobalt complexes of 2,2'-bipyridine. A prominent reaction product of the catalyzed reduction is 1,5-hexadiene. Voltammetry, coulometry, and gas chromatographic data are presented and analyzed and a mechanistic scheme proposed to. account for the catalytic action of the cobalt-2,2'-bipyridine complexes. Rece...

The crystal structure of cyclic AMP-catabolite activator protein (CAP) from Escherichia coli containing cobalt(II) chloride and ammonium sulfate is reported at 1.97 Å resolution. Each of the two CAP subunits in the asymmetric unit binds one cobalt(II) ion, in each case coordinated by N-terminal domain residues His19, His21 and Glu96 plus an additional acidic residue contributed via a crystal co...

Alcoholato Complexes, Cobalt(II) Chlorides Alcoholato complexes of cobalt(II) chloride with the general formula, C0CI2 • x R O H (where R = Me, Et, Pr», Bu», Bu«, Bu* and Bu') have been synthesised by the reactions of anhydrous C0CI2 with an excess of the appropriate alcohols under reflux. Physicochemical studies such as electronic, infra-red spectra, magnetic and conductivity measurements have...