نتایج جستجو برای: and spl
تعداد نتایج: 16827351 فیلتر نتایج به سال:
BACKGROUND Severe dengue with severe plasma leakage (SD-SPL) is the most frequent of dengue severe form. Plasma biomarkers for early predictive diagnosis of SD-SPL are required in the primary clinics for the prevention of dengue death. METHODOLOGY Among 63 confirmed dengue pediatric patients recruited, hospital based longitudinal study detected six SD-SPL and ten dengue with warning sign (DWS...
OBJECTIVES Gentamicin (GM) is a commonly used aminoglycoside antibiotic that generates free oxygen radicals within the inner ear, which can cause vestibulo-cochlear toxicity and permanent damage to the sensory hair cells and neurons. Piper longum L. (PL) is a well-known spice and traditional medicine in Asia and Pacific islands, which has been reported to exhibit a wide spectrum of activity, in...
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation of S1P is catalyzed by S1P lyase (SPL). The human SGPL1 gene that encodes SPL maps to a region often mutated in cancers. To investigate the effect of SPL deficiency on cell survival and tran...
A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. Different E(spl) proteins can functionally substitute for each other, hampering loss-of-function genetic analysis and raising the question of whether any specialization exis...
This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm. This enzyme drives irreversible degradation of sphingosine 1-phosphate (S1P), a bioactive lipid associated with resistance to therapeutics in various cancers, including prostate adenocarcinoma. In fresh human prostatectomy specimens, a remarkable decrease in SPL enzymatic...
SPL (Single Port Laparoscopy) might bring improved surgical outcomes but this new procedure needs effective and functional next-generation surgical tools. Although several robotic systems for SPL have been constructed, only manual SPL tools are currently used in clinical SPL procedures. This paper presents the design, construction and experimental characterizations of a stereo handheld camera t...
This paper examines the use of Service-Oriented Architecture (SOA) services as core assets in a Software product Line (SPL). After a brief introduction to the main concepts of SOA and SPL, the paper identifies a small set of decisions that are required before implementation of SOA-SPL systems. These decisions have to do with 1) the mapping of SOA concepts to the SPL framework, and 2) an initial...
A centerpiece of modern software development is refactoring. Software Product Lines (SPLs), a major software development paradigm, lack tools to refactor Java SPL codebases. X15 introduces our new set of design guidelines, techniques, and language constructs to (1) express feature-based Java SPLs using only Java custom annotations, (2) view programs of the SPL, (3) edit views, automatically pro...
microrna (mirna)ها در بسیاری از فرایندهای مرتبط با تکثیر، رشد و نمو و پاسخ گیاه به تنش¬های زنده و غیرزنده نقش دارند. فاکتورهای رونویسی spl که توسط mirnaها کنترل می¬شوند، اختصاصی گیاهان بوده و در بسیاری از فرایندهای مرتبط با نمو بافت، پاسخ به تنش¬های زنده و غیرزنده و تحریک و فعال¬سازی سایر فاکتورهای رونویسی و پروتئین¬های غشایی نقش دارند. در این تحقیق mirnaهای کنترل¬کننده تنظیم بیان فاکتورهای رون...
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