BACKGROUND There is substantial evidence that androgens may play a role in determining sex-specific blood pressure. Men are at higher risk for developing coronary heart disease or hypertension compared to premenopausal women. However, effects of androgens on the renal and cardiovascular system are complex. This review provides a critical overview of testosterone actions. METHODS We searched P...

Macrophage Fcg receptors (FcgRs) play an important role in the host defense against infection and in the pathophysiology of immune cytopenias. Modulation of macrophage FcgR expression is a potential therapeutic approach to immune disorders. Glucocorticoids and progesterones decrease macrophage FcgR expression. We assessed the effect of treatment with androgens and antiandrogens on the expressio...

Androgens are essential for development, growth, and maintenance of penile structure, and regulate erectile physiology by multiple mechanisms. Here we provide a concise overview of the basic research findings pertaining to androgen modulation of erectile tissue architecture and physiology. A significant body of evidence exists pointing to a critical role of androgens in erectile physiology. Stu...

The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone indu...

background: polycystic ovary syndrome (pcos) is one of the most common reproductive disorders in women. previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of pcos. objectives: in the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of test...

background: testosterone and its metabolites have important roles in learning and memory. the current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal ca1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...