difficult diagnosis in endocrinology, gynecology, and reproductive medicine. to help solve this issue, the rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion, in addition to hyperandrogenism and oligo-anovulation. unfortunately, its assessment does not offer sufficient reliability worldwide. objective: to explore the possible rol...

To determine if insulin-like growth factor binding protein-3 (IGFBP-3) can directly modulate the hormone-dependent steroidogenesis of thecal cells in vitro, thecal cells from large (≥ 8 mm) follicles were collected from cattle and cultured for 4 d. IGFBP-3 inhibited IGF-I-induced thecal cell progesterone and androstenedione production by 52% and 89%, respectively. In contrast, IGFBP-3 had no ef...

Androstenedione is a steroid hormone and the major precursor to testosterone. It is available without prescription and taken with the expectation that it will be converted to testosterone endogenously and increase strength and athletic performance. The metabolism of orally administered testosterone has not been well studied. We randomly assigned 37 healthy men to receive 0, 100, or 300 mg oral ...

One hundred and twenty five patients with polycystic ovaries on ultrasonography and 17 controls with normal ovaries on ultrasound and regular ovulary cycles underwent clinical and endocrine evaluation. Of 125 ultrasound-diagnosed polycystic ovary patients (PCO) 49.6% complained about hirsutism, 55.2% had menstrual disturbances (46.4% oligomenorrhea, 8.8% amenorrhea), 23.2% had normal but irregu...

Sorensen PW, Pinillos M, Scott AP (2005) Sexually mature male goldfish release large quantities of androstenedione into the water where it functions as a pheromone. General and Comparative Endocrinology 140: 164– 175. Walton JC,Waxman B, Hoffbuhr K, Kennedy M, Beth E, Scangos J, Thompson RR (2010) Behavioral effects of hindbrain vasotocin in goldfish are seasonally variable but not sexually dim...

This study explores the potential relationship between social behavior (aggression, dominance, and affiliation) and testosterone, androstenedione, and DHEA measurements in 5-year-old children while also analyzing the moderating effect of IQ on the hormone-behavior relationship. 129 healthy normal Iberian children (60 boys and 69 girls) were videotaped in free play interactions in the school pla...

Endogenous androgens have been suggested as determinants of risk of prostatic cancer. To examine this possibility, baseline sex hormone levels were measured in 1008 men ages 40-79 years who had been followed for 14 years. There were 31 incident cases of prostatic cancer and 26 identified from death certificates with unknown dates of diagnosis. In this study, total testosterone, estrone, estradi...

BACKGROUND Accumulating evidence suggests that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA axis) is involved in depression. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert cortisone to active cortisol and is implicated in HPA axis regulation in animal studies. The aim of our study was to identify polymorphisms in 11β-HSD1 gene (HSD11B1) with consistent associ...