Neural tube defects (NTD) are severe congenital malformations and can be fatal. These malformations constitute one of the principal causes of mortality and morbidity in childhood. Classically, NTD have been divided into two main groups: (a) defects affecting cranial structures, such as anencephaly and encephalocele, and (b) defects involving spinal structures (spina bifida) (Verrotti et al., 20...

A study of 533 women with very low urinary oestriol excretion during the third trimester of pregnancy showed an incidence of major fetal malformations among their infants of 7-1% and a perinatal mortality rate of 14-6%. Thirteen of the malformations were cases of anencephaly, and 26 of the 78 perinatal deaths were due to or associated with major fetal malformations. The incidence of these compl...

A 29-year-old pregnant woman with parity 0-0-0-0 was diagnosed with monoamniotic twin pregnancy discordant for anencephaly at 14 weeks gestation. Umbilical cord entanglement, which is an important cause of fetal death in monoamniotic twins, was confirmed by three-dimensional ultrasound. Cesarean section was performed at 34 weeks of gestation, and the normal newborn infant was discharged without...

abstract objective neural tube defects including anencephaly, encephalocele, and spina bifida are major congenital malformations with multifactorial etiology, and with a great variation in their prevalence in different populations. the study on the prevalence of these malformations may be helpful in planning strategies for their prevention. the aim of this epidemiologic descriptive study was to...

The necropsy reports of 294 cases of anencephaly and 50 cases of iniencephaly have been examined, and a tubulated list of associated malformations produced. Cases were divided by sex and the presence or absence of spina bifida. Forty-one per cent of the series had other malformations, and other malformations were more common in those cases with spina bifida than in those without. The most frequ...

SUMMARY Antenatal ultrasonography has an important rule in diagnosis of congenital malformation. At present identification of most major congenital abnormality during pregnancy depends on . sensitivity and resolution of the instrument, skilful and experienced sonologist and gestational age. Cranial and spinal defects and other malformations can be ferquently diagnosed with ultrasound. Major a...

RATIONALE Sirenomelia and anencephaly are well-defined congenital malformations that usually occur independently. PATIENT CONCERNS We report a case of combined sirenomelia, anencephaly and complete rachischisis, diagnosed in the 16th week of gestation. DIAGNOSES To our knowledge, this is the 7th case in the literature and the first that is diagnosed so early in pregnancy. INTERVENTIONS Th...

Rapidly adhering cells (RA cells) from the amniotic fluid of a pregnancy with fetal anencephaly were investigated by immunofluorescence assay with an antiserum against glial cells. After 24 hours' cultivation a high proportion of the cells showed positive glial-specific fluorescence, whereas no staining was seen in cells from samples of normal amniotic fluid. At the 24th week the mother was del...

Acrania is a rare congenital anomaly and characterized by partial or complete absence of the calvarium. Although acrania associated with anencephaly well recognized entity but isolated anomaly. Ultrasound allows early diagnosis this The fetus was found to have completely formed brain, base skull facial structures lacking cranium. Authors present case acrania. Bang. J Neurosurgery 2021; 11(1): 5...