IN THIS review article, we will assess the evidence for the presence and the mechanism of the intrarenal renin-angiotensin system acting as a local hormonal system in the control of renal function. First, we will review the evidence for the presence of a renin-angiotensin system in the kidney. Second, using results of our own and other studies, we will develop the concept that the intrarenal re...

Increases in renal sympathetic nerve activity regulate the functions of the nephron, the vasculature, and the renin-containing juxtaglomerular granular cells. Because increased activity of the renin-angiotensin system can also influence nephron and vascular function, it is important to understand the interactions between the renal sympathetic nerves and the renin-angiotensin system in the contr...

The renin–angiotensin system is important for the regulation of vascular smooth muscle tone, fluid and electrolyte balance, and the growth of cardiac and vascular smooth muscle. A normally functioning renin– angiotensin system contributes to the routine control of arterial blood pressure. A variety of basic and clinical investigations have resulted in a broader understanding of the role of the ...

OBJECTIVE In heart failure atrial natriuretic peptide (ANP) release in response to volume expansion is impaired while the renin-angiotensin system is activated. This study was designed to test the hypothesis that ANP release in heart failure is dependent on an activated angiotensin system. METHODS We studied the ANP and renin-angiotensin systems in a rat model of shunt-induced high-output hea...

Increases in renal sympathetic nerve activity regulate the functions of the nephron, the vasculature, and the renin-containing juxtaglomerular granular cells. Because increased activity of the renin-angiotensin system can also influence nephron and vascular function, it is important to understand the interactions between the renal sympathetic nerves and the renin-angiotensin system in the contr...

Introduction: The brain renin-angiotensin system (RAS) has been reported having a pathological role in age-related impairment in learning and memory. Therefore, angiotensin converting enzyme inhibitors (ACEi) are expected to have positive effects on memory. Longtime treatment with captopril (an angiotensin converting enzyme inhibitor) significantly attenuates the age-related impairment in learn...

INTRODUCTION: The renin angiotensin system (RAS) is classically known as circulating endocrine system, regulating blood pressure and electrolyte homeostasis. The main effector peptide in this system is Angiotensin II (Ang II), which is hydrolized from angiotensin I (Ang I) by the angiotensin converting enzyme (ACE), a key molecule in this system. Angiotensin I, however, is cleaved from angioten...