the batch fermentation production of human growth hormone (hgh) was studied in a newrecombinant escherichia coli. the effect of different levels of dissolved oxygen and glucoseconcentration on cell density and substrate utilization were evaluated. the results indicated that theoptimum level of dissolved oxygen was 25% of air saturation. the specific growth rate reached amaximum for an optimal g...

introduction: this research was aimed at examining acute responses of hormones such as growth hormone (gh), total testosterone (tt), free testosterone (ft), free fatty acid (ffa) and cortisol to resistance (r), endurance (e) and endurance-resistance (er) exercise. methods: the participants of this study were 10 healthy young men. r protocol included bench press, lateral pull down, leg extension...

Ischemic and nonischemic cardiomyopathies are associated with significant morbidity and mortality in industrialized countries. Cardiomyopathies of primary origin, and more specifically the dilated form of the disease, have been associated with a number of gene defects in cytoskeletal, membrane, and sarcomeric proteins. Cardiomyopathies of secondary origin such as ischemic cardiomyopathy remain ...

SOCS (suppressor of cytokine signalling) proteins, also known as SSI (stat-induced stat-inhibitor) proteins, are negative regulators of cytokine-induced signal transduction. Cytokines regulate cellular behaviour by interacting with receptors on the plasma membrane of target cells and activating intracellular signal transduction cascades such as the JAK-STAT pathway (Krebs and Hilton, 2000.) Met...

Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein h...

There is a large body of evidence that biological aging is related to a series of long-term catabolic processes resulting in decreased function and structural integrity of several physiological systems, among which is the cardiovascular system. These changes in the aging phenotype are correlated with a decline in the amplitude of pulsatile growth hormone secretion and the resulting decrease in ...

In the infantile animal the reproductive organs gradually develop but do not begin to function as organs of reproduction until the age of puberty, although their internal secretions begin before this time. In the female the cause for their functioning lies outside the ovary itself, for immature ovaries transplanted into adults begin to function immediately, whereas adult ovaries transplanted in...