OBJECTIVE Kallmann syndrome (KS) is a genetic disorder with the distinctive features of hyposmia or anosmia and hypogonadotropic hypogonadism. Though hyposmia/anosmia can be evaluated by both objective and subjective smell tests, there is no study comparing these two methods in KS. The aim of the present case series was to discuss the results of objective and subjective smell tests and compare ...

OBJECTIVE To determine appropriate counseling of patients with olfactory dysfunction. DESIGN Retrospective analysis. SETTING Interdisciplinary Center for Smell and Taste, University of Dresden Medical School, Technical University of Dresden. PATIENTS A total of 361 males and 533 females, aged 11 to 84 years, who twice reported to the Interdisciplinary Center for Smell and Taste. MAIN OU...

Chronic olfactory disorders, including the complete loss of the sense of smell (anosmia), are common. Using voxel-based morphometry (VBM) in magnetic resonance imaging (MRI), structural changes in the cerebral gray matter (GM) of a group of patients with anosmia compared with a normosmic, healthy control group were evaluated. Patients with anosmia presented a significant decrease of GM volume m...

COVID-19 telah menjadi pandemi global yang memakan korban jiwa. Pandemi ini menyerang berbagai kalangan usia dengan gejala berbeda-beda pada masing-masing individu. Salah satu umum ditimbulkan adalah gangguan penciuman disebut anosmia. Kondisi menyebabkan penderita kesulitan dalam mencium bau. Tujuan penelitian untuk mengetahui adanya anosmia sebagai penanda dari tahap awal infeksi SARS-CoV-2 d...

OBJECTIVE Patients treated with surgical clipping for anterior communicating artery (A-com) aneurysm often complain of anosmia, which can markedly impede their quality of life. We introduce a simple and useful technique to reduce postoperative olfactory dysfunction in A-com aneurysm surgery. METHODS We retrospectively reviewed the medical records of patients who underwent surgical clipping fo...

BACKGROUND Voltage-gated sodium channel Nav1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic neurons within the peripheral nervous system. Homozygous or compound heterozygous loss-of-function mutations in SCN9A, the gene which encodes Nav1.7, cause congenital insensitivity to pain (CIP) accompanied by anosmia. Global knock-out of Nav1.7 in mice is neonatal lethal rep...

BACKGROUND Cases with essential tremor (ET) have been described with Lewy body inclusions, the hallmark of Parkinson disease (PD). Patients with PD may suffer from anosmia, depression, constipation, and rapid eye movement sleep behavior disorder (RBD), sometimes years before the appearance of their motor syndrome. The objective of this study was to evaluate the prevalence of these non-motor Par...