The identity of the claustrum as a part of cerebral cortex, and in particular of the adjacent insular cortex, has been investigated by connectivity features and patterns of gene expression. In the present paper, we mapped the cortical and claustral expression of several cortical genes in rodent and macaque monkey brains (nurr1, latexin, cux2, and netrinG2) to further assess shared features betw...

The connections between the claustrum and the cortex in mouse are systematically investigated with adeno-associated virus (AAV), an anterograde viral tracer. We first define the boundary and the three-dimensional structure of the claustrum based on a variety of molecular and anatomical data. From AAV injections into 42 neocortical and allocortical areas, we conclude that most cortical areas sen...

The author discusses the claustrum as an aspect of pathological containment within inner space and its relation to Bion's (1962a, b) container-contained concept. Having outlined the early psychoanalytic conceptual foundations of claustrophobia and the claustrum, the author charts the term from its introduction by Erikson in 1937 through its divergent developmental trajectories within the concep...

The claustrum is among the most enigmatic of all prominent mammalian brain structures. Since the 19th century, a wealth of data has amassed on this forebrain nucleus. However, much of this data is disparate and contentious; conflicting views regarding the claustrum's structural definitions and possible functions abound. This review synthesizes historical and recent claustrum studies with the pu...

Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., 2014), but an important question remains: do they receive inputs from the same or different brain areas or neurons? To answer this question, we first located flexible and stable value-coding areas in the caudate head (CDh) and caudate tail (CDt) of two rhesus maca...

The connections between two parts of the claustrum in the rat and rabbit were studied using the highly fluorescent lipophilic carbocyanine dye (Dil). After the application of Dil crystal into the endopiriform nucleus, labeled fibers in the insular claustrum were observed in its part directly neighboring the insular cortex and capsula externa. Additionally, numerous projections into the piriform...

OBJECTIVE We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. RESULTS The analysis revealed significant inverse correlations between r...

CONTENTS Introduction ........................................................ Nuclear arrangement in the teleneephalon .............................. The olfactory bulb ............................................... The accessory olfactory bulb ..................................... Nucleus olfactorius anterior ...................................... The nuclear groups in the ventromedial porti...

The physiology of control and suppression of natural urges is not well understood. We used [(15)O]H(2)O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found...

In 13 cats and 5 dogs various parts of the frontal lobe were removed. As a result terminal degenerations in the rostral quarter of the insular claustrum were found by Nauta and Fink-Heimer II methods. In cats with motor cortex lesions, the degenerations were localized more dorsally than in cats with removals of the frontoorbital cortex, but there is a large overlap between degenerating areas of...