The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

Ferula persica, is the well-known species of the genus Ferula in Iran and has two varieties: persica and latisecta. They have both been extensively used in traditional medicine for a wide range of ailments. A great number of chemical compounds including sesquiterpene coumarins and polysulfides have been isolated from this plant. Fresh plant materials, crude extracts and isolated components of F...

objective: triptolide, the active component of tripterygium wilfordii hook f has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional chinese medicine. however, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. in this review, we discuss the autoimmune disorders and inflammatory condition...

Background and Aim: The aim of this study was to detect the organic compounds of Onopordon leptolepis DC. and also evaluate the anticancer and anti-oxidant effects of the plant extract on CaCO2 cells. Materials and Methods: The effective compounds of air branches of Onopordon leptolepis DC. were studied using phytochemicals methods. Using GC-MS device the components of  ethanolic extract ...

Artocarpus camansi (AC) has been long used by Indonesian local people as food and traditional medicine. This study aims to explain the relationship between use of AC a ingredient medicine its bioactivity. The method in writing this article is literature on various scientific articles published online at Google Scholar using AC, uses bioactivities. results obtained were synthesized so be able bo...

Objective(s):Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms. Telomerase, a ribonucleoprotein reverse transcriptase, is responsible for elongation of the telomere and is activated in cancers. A relation between telomerase activity and resistance to apoptosis has been established. T...

Background: CD90, a membrane-associated glycoprotein is a marker used to identify mesenchymal stem cells (MSCs). Recent studies have introduced CD90, which induces tumorigenic activity, as a cancer stem cell (CSC) marker in various malignancies. Blocking CD90 activity with anti-CD90 monoclonal antibodies enhanced anti-tumor effects. To date, highly specific antibody single-chain variable fragme...

Abstract In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing with previous literature data. This is the first report of the isolation ...

Abstract In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing with previous literature data. This is the first report of the isolation ...