RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...

High titers of autoantibodies directed to isotypic determinants of IgD were produced by inoculation of syngeneic monoclonal IgD, conjugated covalently to keyhole limpet hemocyanin, into adult or neonatal inbred mice. Anti-idiotypic antibodies were induced at the same time. The average affinity of the mouse antibodies (Ka approximately equal to 10(7) M-1) is similar to that of rabbit anti-IgD an...

Bakcground: The aim of ITP treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. This study was conducted with the objective of comparing the efficacy of anti-D immunoglobulin (Ig) with dexamethasone in treating childhood ITP. Materials and Methods: In this randomized prospective control trial, 20 ITP patients (Platelet count<20,000/&micro;l) younger th...

Abstract Hemolytic disease of the fetus and newborn (HDFN) remains main cause fetal anemia primarily due to RH-D maternal incompatibility but also other rarer antigens. Anti-Kell mediated immunization is a rare involving about 0.1% pregnant women causing more severe HDFN compared both for its mechanism because lack preventive immunoglobulin therapy. Although standard treatment intrauterine tran...

Events following which anti-D immunoglobulin should be given to all RhD negative women with no anti-D antibodies: First trimester indications (50 microg)--termination of pregnancy, spontaneous abortion followed by instrumentation, ectopic pregnancy, chorionic villus sampling, partial molar pregnancy; Second and third trimester indications (100 microg)--amniocentesis, cordocentesis, other invasi...

EndoS from Streptococcus pyogenes is an immunomodulating enzyme that specifically hydrolyzes glycans from human immunoglobulin G and thereby affects antibody effector functions. Autoimmune hemolytic anemia is caused by antibody-mediated red blood cell (RBC) destruction and often resists treatment with corticosteroids that also cause frequent adverse effects. We show here that anti-RhD (anti-D) ...

Passively administered IgG antibodies can temporary prevent the antibody response to the corresponding antigen. This phenomenon of antibody-mediated immune suppression has been successfully applied in clinical practice: administration of polyclonal anti-RhD immunoglobulin to Rh-negative women during and after pregnancy is a very effective measure for the preventing D immunization by D-positive ...