نتایج جستجو برای: anti leishmanial activity
تعداد نتایج: 1421973 فیلتر نتایج به سال:
The need for drug combinations to treat visceral leishmaniasis (VL) arose because of resistance to antimonials, the toxicity of current treatments and the length of the course of therapy. Calcium channel blockers (CCBs) have shown anti-leishmanial activity; therefore their use in combination with standard drugs could provide new alternatives for the treatment of VL. In this work, in vitro isobo...
ABSTRACT Background and Objectives: Due to adverse effects of pentavalent antimonial treatment of visceral leishmaniasis using herbal medicines has received a lot of attention. In this study, we evaluated inhibitory activity of Pelargonium roseum essential oil on growth of Leishmania infantum promastigotes, and compared it with that ...
Informative title: Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse
11 Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania and 12 affects approximately 10 million people worldwide. Currently available drugs are not ideal due to high 13 cost, toxicity, parenteral administration and suboptimal efficacy. Miltefosine is the only oral 14 treatment (Impavido®) available to treat CL, given over a period of 28 days with common...
BACKGROUND Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosin, and allopurinol. In this study, we explained about the native plant that grows in different regions of Iran and used as anti-leishmanial in Iran and even many other countries. METHODS This narrative review covers all information about local herbal medicine in Iran that used in ...
ABSTRACT Background and Objectives: Leishmaniasis is a public health problem caused by the protozoan Leishmania. Pentavalent antimonials are currently used for treatment of leishmaniasis, but they have serious side effects. Nerium oleander L. has been used in traditional medicine due to its various health-protective propertie...
Surfactant protein A (SP-A) is a hydrophilic pulmonary protein belonging to the collectin family, involved in lung homeostasis, the regulation of host defenses and inflammation. The present study addresses the activity of SP-A against promastigotes and amastigotes of Leishmania amazonensis and its cytotoxicity for host cells. SP-A exhibited similar activity against both parasite forms, with an ...
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