background: bacterial dna has immunostimulatory effects on different types of immune cells such as dendritic cells (dcs). application of dcs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. objectives: to investigate the effect of tumor antigen pulsed dcs in the presence of cpg-1826 in treatment of a murine model of cancer. methods: ...

The anti-tumor agent, (Z)-3-(chloromethylene)-6-chlorothiochroman-4-one, could inhibit tumor cell proliferations. However, the anti-tumor activity in vivo is poorly understood. So we research the anti-tumor activity in vitro and in vivo, and the probable anti-tumor mechanism systematically in this study. The results showed that the compound CMCT was effective with tumor as the concentration-dep...

Background: Bacterial DNA has immunostimulatory effects on different types of immune cells such as dendritic cells (DCs). Application of DCs as a cellular adjuvant represents a promising approach in the immunotherapy of infectious disease and cancers. Objectives: To investigate the effect of tumor antigen pulsed DCs in the presence of CpG-1826 in treatment of a murine model of cancer. Methods: ...

in this study a 3-factor, 3-level box-behnken design was used to prepare optimized docetaxel (dtx) loaded pegylated poly lactide-co-glycolide (peg-plga) nps with polymer concentration (x1), drug concentration (x2) and ratio of the organic to aqueous solvent (x3) as the independent variables and particle size (y1), poly dispersity index (pdi) (y2) and drug loading (y3) as the responses. the cyto...

background and objectives: angiogenesis is essential for tumor survival. inhibiting angiogenesis could be a mechanism for hindering tumor development. numerous studies have now been focused on agiogenesis inhibitors and many of such studies have targeted plant materials. in the present study, crocus pallasii subsp. haussknechtii has been evaluated for anti-angiogenesis properties. methods: anti...

T. asthmatica, which belongs to the family Asclepiadaceae is a small twining a plant with long fleshy roots. The plant shows broad activity against EA and DLA cells. The intraperitoneal injection of PE extract obtained from the powdered entire plant material to the tumor cell transplanted animals arrests the tumor growth and prevents the formation of the tumor. A significant increase in the lif...

Alternative splicing has emerged as an important target for molecular therapies. Splice-switching oligonucleotides (SSOs) modulate alternative splicing by hybridizing to pre-mRNA sequences involved in splicing and blocking access to the transcript by splicing factors. Recently, the efficacy of SSOs has been established in various animal disease models; however, the application of SSOs against c...