In the exploration of potential therapeutic agents for rheumatoid arthritis (RA), DBA/1J mice are used as the RA model of collagen-induced arthritis (CIA). Phloretin, a flavonoid compound extracted from Prunus mandshurica, has been found to exhibit anti-inflammatory activity, making it a potential candidate for treatment of RA. The objective of this study was to evaluate the therapeutic effects...

epoxyquinomicins A, B, C, and D, respectively. Therefore, these epoxyquinomicins are unique candidates for antiinflammatory agents. The modeof action appears to be different from that of common NSAIDs(non-steroidal antiinflammatory drugs)3), since epoxyquinomicins C and D did not inhibit cyclooxygenase-1 at the concentration of 300 /iu. The mechanism of the antiarthritic effect has not been elu...

Grangea maderaspatana (L.) Poir. is a popular Indian medicinal plant belonging to the Asteraceae family. This plant commonly known as Madras Carpet grown in wet places. A wide range of phytochemical constituents have been isolated from this plant. It has long been used in traditional Ayurvedic Indian medicine for various diseases. This plant is pharmacologically studied for oestrogenicity, anti...

The copA gene of Escherichia coli encodes a copper transporter and its promoter is normally regulated by Cu(I) ions and CueR, a MerR-like transcriptional activator. We show that CueR can also be activated by gold salts and that Cys(112) and Cys(120) are involved in recognition of gold, silver, and copper salts. Gold activation is unaffected by copper chelating agents but is affected by general ...

betes in man with pituitary adrenocorticotropic hormone, J. Lab. & Clin. Med. 34:255-269, 1949. 4 2 Brown, E. M., Jr., Lukens, F. D. W. , Elkinton, J . R. and De Moor, P. : Observations on the metabolic and antiarthritic effects of ACTH and cortisone in diabetics, J. Clin. Endocrinol. 11:1363-1374, 1950. 4 3 Addis, T., Poo, L. J. and Lew, W . : The rate of protein formation in the organs and ti...

The ethanol Hedera helix plant extract was tested for its antiinflammatory properties. Intraperitoneal injections of 7.5 ml/kg wt ethanol extract showed antiinflammatory activity with 88.89% inhibition as compared to reference drug diclofenac, which showed 94.44% inhibition in formalin-induced paw oedema. As formalin-induced paw oedema closely resembles human arthritis, the antiarthritic proper...