نتایج جستجو برای: antifungal agent
تعداد نتایج: 275171 فیلتر نتایج به سال:
BUMC PROCEEDINGS 2003;16:241–248 Fungal infections remain a significant cause of morbidity and mortality despite advances in medicine and the emergence of new antifungal agents (1). Immunocompromised patients are particularly at risk of developing these infections, with Candida and Aspergillus spp. being the mycoses most commonly identified (2). Patients who develop candidemia have a greater ch...
The antifungal activity of the dealcoholized extract of the leaves of Clerodendrum infortunatum Retz. was determined on four different fungal organisms. The crude leaf extract significantly inhibited the growth of A. niger; P. frequentance; P. notataum and B. cinera when tested by turbidity and spore germination methods in concentration dependent fashion. The effects produced by the extract wer...
High-level production (880 mg liter(-1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp.
effects of different carbon sources on growth and production of antifungal agent(s) by gymnopilus spectabilis were investigated. different carbon sources including; glucose, fructose, lactose, maltose, manitol and sucrose at the concentration of 10 g/l and slow releasing carbon sources including malt extract and soluble starch at the concentration of 2g/l were used. inhibition of spore germinat...
Ascosphaera apis is a bee pathogen that causes bee larvae infection disease, to which treatment is not yet well investigated. The aim of this study was to investigate antifungal susceptibility in vitro against A. apis and to identify a new antifungal agent for this pathogen through minimal inhibitory concentration (MIC) assay and western blot analysis. Macelignan had 1.56 and 3.125 μg/mL MIC ag...
Effects of different carbon sources on growth and production of antifungal agent(s) by Gymnopilus spectabilis were investigated. Different carbon sources including; Glucose, fructose, lactose, maltose, manitol and sucrose at the concentration of 10 g/l and slow releasing carbon sources including malt extract and soluble starch at the concentration of 2g/l were used. Inhibition of spore germinat...
A thaumatin-like protein gene from Basrai banana was cloned and expressed in Escherichia coli. Amplified gene product was cloned into pTZ57R/T vector and subcloned into expression vector pET22b(+) and resulting pET22b-basrai TLP construct was introduced into E. coli BL21. Maximum protein expression was obtained at 0.7 mM IPTG concentration after 6 hours at 37°C. Western blot analysis showed the...
Tolerance of human pathogenic fungi to antifungal drugs is an emerging medical problem. We show how strains of the causative agent of human aspergillosis, Aspergillus fumigatus, tolerant to cell wall-interfering antimycotic drugs become susceptible through chemosensitization by natural compounds. Tolerance of the A. fumigatus mitogen-activated protein kinase (MAPK) mutant, sakADelta, to these d...
Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cation...
In vitro antibacterial and antifungal activity of the chloroform extracts of the root and the stem of Andrographis paniculata at different concentrations were screened against gram positive bacteria Staphylococcus aureus, Bacillus subtilis, gram negative bacteria Escherichia coli, Proteus vulgaris and fungi Aspergillus niger, Penicillium chrysogenum by cup plate method. The extracts were found ...
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