Studies in our laboratory and elsewhere have shown that it is possible to propagate antigen-specific murine T cells in vitro with resultant specific stepwise enrichment of antigen-induced proliferative cells. The proliferative responses of these T cells are antigen specific and dependent upon the presence of antigen-presenting cells (spleen cells) that share the I-A subregion with the prolifera...

The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...

Resistance to immunotherapy is due in some instances the acquired stealth mechanisms of tumor cells that lose expression MHC class I antigen–presenting molecules or downregulate their antigen–presentation pathways. Most dramatically, biallelic ?2-microglobulin (B2M) loss leads complete and invisibility CD8 + T cells. antigen presentation are potently upregulated by interferon-? (IFN?) a manner ...

The immune response to certain synthetic polypeptide antigens and native proteins has been shown to be controlled by immune response (Ir) genes, which reside in the murine major histoeompatibility complex (MHC) 1 (reviewed in 1). The expression of such Ir gene control has been localized to T cells, B cells, and/or antigen-presenting cells (2-4). Support for the concept of Ir gene expression in ...

BACKGROUND Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy. In order to identify a reliable method for producing adequate amounts of functional antitumor cytotoxic T lymphocytes with a potentially long in vivo lifespan, we tested the T-cell expansion efficiency of a new artificial antig...

background: during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. dc are antigen-presenting cells that have an important role in tolerance and autoimmunity. the transforming growth factor-beta1 (tgf-β1) cytokine has a regulatory role on the immune and non-immune cells. the aim of this study is ...

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent mediated immunity against tumor. The outcome antigen-specific T-cells responses relies interaction between and antigen-presenting cells, which provides signals for generating different phenotypes with roles in tumor removal. However, such often not optimal vivo results low efficacy. To reach full po...

Particulate antigen-delivery systems are instrumental for therapeutic vaccination, aiming at improving the safety and efficacy of treatments by targeting specialized antigen-presenting cells (APCs). However, induction potent adaptive immune responses, especially cellular immunity, remains a major challenge. Herein, novel nanoparticulate system based on amphiphilic cyclodextrins (CDs) is develop...