background: the widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. methods: in this study, an attempt was made to explore the niche of novel habitat to isolate pyllospheric bacteria fr...

new sulfonamide and amide derivatives containing coumarin moieties; oxo-2h-chromen-sulfamoylphenylacetamides and oxo-2h-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. the structures of the obtained compounds were elucidated by ir and nmr spectra and also analytical elemental analysis. in the next step, the above mention...

Microbial infections are one of the leading diseases which are responsible for millions of deaths every year because of lack of effective antimicrobial therapy and this situation becomes more complicated because of microbial resistance towards conventional antibiotics. Quinoline derivatives have proved their medicinal importance by having broad spectrum of pharmacological activities like antimi...

abstract background and purpose: in traditional medicine, herbal products still remain the principal source of pharmaceutical agents. the present study aimed to investigate the antifungal effects of echinophora platyloba and rosmarinus officinalis extracts on c. albicans species. materials and methods: the aqueous and ethanolic leaf extracts of e. platyloba and r. officinalis, collected from th...

Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect activities against such pathogens. The structural ...

Six different extracts of Canarium patentinervium Miq. (Burseraceae) leaves and barks were screened for their phytochemical composition, and antimicrobial and free radical scavenging activities. Among the different extracts tested, the ethanol extract of leaves showed significant antimicrobial and radical scavenging activities. The most susceptible micro-organisms were found to be Gram-positive...

The rampant multi-drug resistance among human pathogenic microorganisms has necessitated a continuous search for new and potent antimicrobial substances, especially among plants. Also, the importance of herbal plants as sources of alternative medicine is documented worldwide. In this study, antimicrobial activities of extracts of seven edible mushrooms and two spices (ginger and garlic) against...

It has been unclear to which antimicrobial activities (e.g., anti-gram-positive bacterial, anti-gram-negative bacterial, antifungal, antiparasitic, and antiviral activities) of antimicrobial peptides (AMPs) a given physiochemical property matters most. This is the first computational study using large-scale AMPs to examine the relationships between antimicrobial activities and two major physioc...

In the last three decades investigations in the field of oxadiazoles have been intensified due to their diverse therapeutic uses. Oxadiazole are well known to have a wide range of therapeutic activities namely anti-inflammatory, analgesic, antipyretic, anticonvulsant, antiparasitic, antimicrobial etc. In this study, we have evaluated the antimicrobial activity of some carboxymethyl derivativ...