BACKGROUND Antimicrobial resistance is driven by multiple factors. Resolving the threat to human and animal health presented by drug-resistant infections remains a societal challenge that demands close collaboration between scientists and citizens. We compared current public views about key contributing factors to antimicrobial resistance with those expressed by experts. METHODS Overarching f...

BACKGROUND The misuse of antimicrobial agents increases drug resistance in bacteria. METHODS The correlation between antimicrobial agent consumption and related resistance in the Gram-negative bacteria Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Proteus mirabilis was analyzed during the period 2003-2011. RESULTS Among these five bacteria, ov...

conclusions the findings of the present study well demonstrated that the p. aeruginosa biofilm-producing isolates were more resistant to the tested antibiotics. furthermore, because of wide distribution, it seems that the psla gene is associated with biofilm formation. results biofilm formation was observed in 70% of the p. aeruginosa isolates. the potential formation of biofilm was significant...

antibiotic resistance of intensive care unit (icu) born aerobic gram-negative bacteria was evaluated during a six months period at a teaching hospital in tehran, and determination of the validity of the results obtained from disc diffusion tests, using discs manufactured in iran. disc susceptibility tests using iranian and standard discs (diffusion discs available in international markets) were...

background and objectives: acinetobacter spp. are important causes of nosocomial infections. they possess various antibiotic resistance mechanisms including extended spectrum beta lactamases (esbls). the aim of this study was to determine antibiotic resistance profile of acinetobacter clinical isolates especially among esbl-producing strains and to investigate the antimicrobial effects of oleo-...

backgrounds: different susceptibility rates of pathogenic bacteria to antimicrobial agents are considered major factors in the choice of drugs and the success of treatments. concerns have been raised regarding the emergence of antimicrobial resistance among pathogenic bacteria that may result in unpredictable antimicrobial susceptibilities and therapy failure. objectives: the purpose of this in...

A fast emerging global threat to the health care system is Antimicrobial Resistance (AMR). AMRis development of resistant strains bacteria, viruses and fungi over time, due which commoninfections are difficult treat, leading spread diseases, their increased intensity deaths. The useof antimicrobials since invention in previous century have saved countless human lives, as well asincreased averag...

Multiple factors ranging from globalization to ecosystem disruption are presenting the global community with evolving biological threats to local, national, and global security that reach beyond the realm of traditional bioweapon threats. As a result, mitigation strategies have adapted necessarily to the increased diversity of biological threats. In general, response and preparedness strategies...

Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agen...

The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resist...