Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of d-cycloserine inhibition of mycobacterial growth by d-alanine. J. Bacteriol. 85:1217-1220. 1963.-Reversal of the antimycobacterial activity of d-4-amino-3-isoxazolidinone (d-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, d-alanine was the...

There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Th...

In this study, antibacterial, antifungal, antimycobacterial, cytotoxic, antitumor, cardiovascular, antifeedant, insecticidal, antileishmanial and some other single activities of diterpenoids and norditerpenoids isolated from Turkish Lamiaceae plants, are reviewed. The diterpenoids were isolated from species of Salvia, Sideritis, and Ballota species growing in Anatolia. Fifty abietanes, ten kaur...

Betulinic acid, oleanolic acid and ursolic acid have been modified at the C-3 position to cinnamate-based esters and in vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra has been determined. The results indicated that modification of the parent structures of betulinic acid, oleanolic acid and ursolic acid to the p-coumarate and, in the case of the latter two triterpene...

A 34 year old female developed Mycobacterium avium-intracellulare infection with generalized lymphadenopathy, hepatosplenomegaly, pulmonary infiltration, pleural effusion and endobronchial polypoid lesions. M. avium-intracellulare was identified by means of sputum cultures, pleural effusion culture and lymph node culture. The anti-human immunodeficiency virus (HIV) antibody was negative. The CD...

Malabsorption of oral antimycobacterial drugs is a rare cause of treatment failure in tuberculosis (TB). Several predisposing comorbidities have been recognised. HIV infection is the most important risk factor referred in the literature. There are few reports about antimycobacterial drugs malabsorption, particularly in the absence of predisposing comorbidities. The authors present a clinical ca...

As a continuation of our efforts in developing new antimycobacterial agents, a series of new 1,3-thiazolidine-2-thione derivatives were synthesized. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. The analysis of theoretical toxicity risks,drug-likeness and drug-score for these series using Osiris program showed acceptable results.

TO THE EDITOR—The report on the intrinsic antimycobacterial activity of ibupro-fen and low-dose aspirin in a novel murine tuberculosis model is fascinating