Background: To clarify if a2-macroglobulin (a2M) has an antioxidative effect during the progression of intervertebral disc degeneration (IVDD). Methods: The content a2M and reactive oxygen species (ROS) were measured to compare mildly severely degenerated human nucleus pulposus (NP) tissue by immunohistochemistry, mass spectrometry, enzyme-linked immunosorbent assay (ELISA). Additionally, exoge...

the objective of this study was to evaluate the effect of dietary supplements with lead acetate and aluminosilicates (atn) on antioxidative enzyme activities and lipid peroxidation of the heart and skeletal muscle tissues of broiler chickens. broilers were allotted to four diets including the control group, the pb group, the aluminosilicate-atn (antitoxic nutrient) group and the pb+atn group, i...

Abstract Atmospheric warming and increasing tropospheric ozone (O3) concentrations often co-occur in many cities of the world including China, adversely affecting health status urban trees. However, little information is known about combined interactive effects from increased air temperature (IT) elevated O3 (EO) exposures on tree species. Here, Ginkgo biloba Populus alba ‘Berolinensis’ seedlin...

AIM To estimate the impact of high fat diet and estrogen deficiency on the oxidative and antioxidative status in the liver of the ovariectomized rats, as well as the ameliorating effect of physical activity or consumption of functional food containing bioactive compounds with antioxidative properties on oxidative damage in the rat liver. METHODS The study was conducted from November 2012 to A...

tobacco smoke contains numerous compounds, many ‎of which are oxidants and capable of producing free radical and enhancing ‎the oxidative stress. the aim of this study was to investigate the effect of cigarette smoking on the erythrocyte antioxidative enzyme activities and the plasma ‎concentration of their cofactors. ‎sixty eight healthy men were enrolled, 32 of whom had never smoked and 36 ha...

Reactive oxygen species (ROS), such as superoxide anion radicals (O.-2) and hydrogen peroxide (H2O2) are potentially harmful by-products of normal cellular metabolism that directly affect cellular functions. ROS is generated by all aerobic organisms and it seems to be indispensable for signal transduction pathways that regulate cell growth and reduction-oxidation (redox) status. However, overpr...

Lipid auto-oxidation in milk is affected by a complex interplay of proand antioxidants. Several of these compounds are also important nutrients in the human diet and may have other physiological effects in the gastrointestinal tract and other tissues. Among antioxidative enzymes superoxide dismutase catalyses the dismutation of superoxide anion to hydrogen peroxide. The degradation of hydrogen ...