OBJECTIVE This study examined trends in the prescription of antipsychotic drugs in a nationally representative sample of physicians in nonfederal office-based clinical practice during the 1990s. METHODS The authors analyzed physician-reported data from annual National Ambulatory Medical Care Surveys between 1989 and 1997 using weighted national estimates of physician visits during which antip...

objectives: the aim of this study was to investigate the prevalence and its determinants of antipsychotic use in patients with psychiatric disorders. materials and methods: this study was on patients with psychiatric disorder that have discharged from the hospital. we have assessed all patients with psychiatric interview and evaluation of their psychiatric documentations. results: 90.7% of all ...

OBJECTIVE To investigate the patterns of antipsychotic use in China and to analyze the factors that influence antipsychotic prescriptions. METHODS A standardized survey was conducted from May 20 to 24 2002 in five different regions of China with varying economic levels. The patterns of antipsychotic medication use were analyzed in a sample of 4,779 patients with schizophrenia. The survey gath...

Introduction The introduction of the first antipsychotic agents in the 1950s marked a dramatic improvement in the care for individuals with schizophrenia and other forms of severe and persistent mental illness. The discovery of antipsychotic medications encouraged medical science’s more systematic investigation of the biological underpinnings of schizophrenia and the development of additional a...

And there is more, much more. If the FDA enforces these requirements, drug companies would probably not be sending around dubious articles based on bogus clinical trials, which is Waxman’s concern. The bigger risk is that physicians might not pay close enough attention to the risks of off-label use, which can be substantial. These risks come into play in connection with atypical antipsychotic a...

This article examines trends in antipsychotic medication use in a treated population of publicly funded patients with schizophrenia between 1991 and 1996. Findings from administrative claims data show that antipsychotic prescription rates increased from 79 percent to 83 percent between 1991 and 1996. Atypical antipsychotics were used by 39 percent of the population and comprised 41 percent of a...

The mechanism of action of antipsychotic drugs is mainly associated with changes in dopaminergic system. The application of antipsychotic agents simultaneously produces changes in concentrations of metabolites (e.g. kynurenic acid - KYNA, 3-hydroxykynurenine - 3-OHKYN, kynurenine - KYN) of the kynurenine pathway, the pathway engaged in glutamatergic transmission. The increase in KYNA levels in ...

Adenylate cyclase (EC 4.6.1.1), selectively stimulated by low concentrations of dopamine, has been found in the olfactory tubercle, the nucleus accumbens, and the caudate nucleus of several mammalian species. Several different classes of drugs effective in the treatment of schizophrenia (antipsychotic drugs) were potent inhibitors of the stimulation by dopamine of the enzyme from these various ...

Diabetes and mental disorders are common chronic illnesses in the United States, affecting more than 16 million and 44.3 million Americans, respectively. As a result of the ever-increasing incidence of obesity, diabetes is being diagnosed more often, not only in the adult population but also in children. Additionally, more focus is being given to behavioral disorders in recent years, and the He...