The aim of this study was to improve wettability and dissolution rate of a poorly water-soluble drug, cilostazol, using the supercritical antisolvent (SAS) process. The solid state of particles precipitated from dichloromethane containing additives, including poloxamer 188, poloxamer 407, TPGS 1000, Gelucire 44/14 and Gelucire 50/13, in supercritical CO(2) medium were characterized by different...

This study aimed to prepare the aminoclay-lipid hybrid composite to enhance the drug release and improve the oral bioavailability of poorly water-soluble fenofibrate. Antisolvent precipitation coupled with an immediate freeze-drying method was adopted to incorporate fenofibrate into aminoclay-lipid hybrid composite (ALC). The optimal composition of the ALC formulation was determined as the rati...

Propolis is used by bees for holding a hive together, and for sterilizing the hive against microbial infections. Propolis contains a high concentration of flavonoids, which are used in a wide range of cosmetic and health food preparations for their antimicrobial properties. Propolis is usually dissolved in ethanol or ethanol/water mixtures to produce a tincture, and to remove insoluble material...

Coaxial flow injection and mixing of solvent antisolvent flows prevent contact the lipid solution with microchannel walls enable stable continuous precipitation monodisperse nanoparticles in order 150 nm below.

An effective way to ensure proper mixing and thereby realize maintenance-free operation of the clogging-sensitive continuous tubular crystallizers is utilization ultrasound-irradiation. Considering this, our research aimed develop an ultrasonicated plug flow crystallization process separate purify a multicomponent acetylsalicylic acid (ASA) reaction mixture with antisolvent combined cooling-ant...

This paper describes the separation of two of the most widely used explosive compounds, RDX (1,3,5-Trinitro-1,3, 5-triazacyclohexane) and HMX (1,3,5,7-tetranitro-1,3,5,7tetraazacyclooctane). A simple antisolvent phase separation process to obtain >99% pure RDX from an explosive mixture consisting of RDX (≈90%) and HMX (≈10%) was developed. The process does not require modifications to the exist...

The purpose of this work was to explore the particle size reduction effect of carvedilol on dissolution and absorption. Three suspensions containing different sized particles were prepared by antisolvent precipitation method or in combination with an ultrasonication process. The suspensions were characterized for particle size, surface morphology, and crystalline state. The crystalline form of ...