Butter is separated from cream using ultrasonication method. The efficiency of butter preparation is evaluated with respect to various parameters such as time, dilution, fermentation time using ultrasonication at room temperature and compares the yield with conventional stirring method. All the parameters were critically studied and it is observed maximum yield was obtained for sonication time ...

Abstract Microfluidic processes are of interest for the production pharmaceutical nanoparticles due to uniform characteristics attainable by such devices. However, precipitation in microfluidic systems incur a high risk fouling, which compromises their reliability continuous operation. A robust ultrasound‐assisted process is established lipid mixer. The results indicate that can be produced ove...

Background This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques. Methods The method employed a 3D microfluidic geometry whereby two different phases - solvent and antisolvent - were introduced at either side of a 1 μm thick resonating membrane, ...

Objective: The aim of this work was to investigate and compare various practical techniques to enhance dissolution of ezetimibe, a Class II Biopharmaceutics Classifi cation System compound. Ezetimibe is a poorly soluble compound with variable oral bioavailability. Nanosuspensions, hydroxypropyl-beta-cyclodextrin (HPβCD) complexes as well as combination of surfactant were techniques investigated...

In an era where sustainability is becoming the main driving force for research and development, supercritical fluids-based techniques are presented as a very efficient alternative technology to conventional extraction, purification, recrystallization processes. Supercritical antisolvent (SAS) precipitation novel technique that can replace liquid techniques. Additionally, through optimization of...

A stochastic formulation for the description of cooling-antisolvent mediated crystal growth processes based on the Fokker-Planck equation is discussed. Previous results are further extended to include not only the additional degree of freedom (temperature) in the approach, but also to formulate the model parameters dependencies with the input manipulated variables (antisolvent flow rate and tem...

Voriconazole is a second-generation antifungal agent with excellent broad spectrum of antifungal activity commercially available for oral and intravenous administration. Systemic administration of voriconazole is associated with side effects including visual and hepatic abnormalities. This study assessed the feasibility of using solid lipid nanoparticles for ocular delivery of voriconazole adop...