BACKGROUND Though autoimmune phenomena have been regularly associated with chronic urticaria in adults, data in children are sparse. AIM To describe our experience with children and adolescents with chronic urticaria and autoimmunity. METHODS AND RESULTS Of 187 patients referred for evaluation of chronic urticaria during a 7.5 year period, eight (4.3%), all females aged 7-17 years, had incr...

Objectives: To find an association between circulating oestradiol and thyroid autoimmunity in females with polycystic ovarian syndrome (PCOS) its impact on their health. Materials Methods: This study was conducted at Aziz Fatimah Medical Dental College, after obtaining ethical approval from Institutional Ethical Committee (letter No. DME/568-19) April to September 2017. Hundred PCOS enrolled th...

Background Inflammation of the orbital connective tissue, extraocular muscles and upper eyelids occurs in about 40% of patients with Graves hyperthyroidism [Graves Ophthalmopathy (GO)] while mild eye signs including upper eyelid retraction are found in as many as 25% of patients with Hashimoto thyroiditis and, occasionally, transient thyroiditis. Some workers have proposed a relationship betwee...

Genetic factors are thought to be an important determinant of thyroid function and autoimmunity. However, there are limited data on genetic variants in Asians. In this study, we performed a genome-wide association study on plasma thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration and anti-thyroid peroxidase (anti-TPO) antibody positivity in 4238 Korean subjects. In the Sta...

Background Inflammation of the orbital connective tissue, extraocular muscles and upper eyelids occurs in about 40% of patients with Graves hyperthyroidism [Graves Ophthalmopathy (GO)] while mild eye signs including upper eyelid retraction are found in as many as 25% of patients with Hashimoto thyroiditis and, occasionally, transient thyroiditis. Some workers have proposed a relationship betwee...

: Chronic lymphocytic thyroiditis is autoimmune thyroiditis; it considered as second most common thyroid disorder diagnosed on FNAC following colloid goitre. a reliable and efficient method for diagnosing these lesions. Lymphocytic frequently affects women, primarily compared to men commonly found with hypothyroidism, euthyroidism or every so often hyperthyroidism. The incidence rate of Hashimo...

OBJECTIVE To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group. METHODS Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013-Feb 2014. Ninety cases of women with PCOS based on Rotterdam's criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase...

OBJECTIVE: Diabetes mellitus and thyroid disease are the two common endocrinopathies seen in adult population. Studies to evaluate thyroid disorders in patients with type 2 diabetes are lacking. The aim of this study was to compare prevalence of thyroid dysfunction and autoim-munity in type 2 diabetic patients with age and sex matched non-diabetic control group. MATERIAL AND METHODS: Among pat...

To determine if introduction of iodized salt induces thyroid autoimmunity in goitrous children, we conducted a prospective trial in iodine-deficient Moroccan schoolchildren (n = 323). Local salt was iodized at 25 microg iodine per gram of salt and distributed to households. Before introduction of iodized salt and at 10, 20, 40, and 52 weeks, we measured antithyroid peroxidase antibodies (TPO-Ab...

Thyroid peroxidase (TPO) was purified from each thyroid of 10 patients (experiment 1) and 4 patients (experiment 2) with toxic diffuse goiter by a simplified method with monoclonal anti-TPO antibody-assisted immunoaffinity column chromatography. The final preparations were used to measure the heme concentration based on the cyanide difference spectrum, and to determine the Km and kcdt values fr...