The corticotropin-releasing factor (CRF) system mediates stress responses. Extrahypothalamic CRF1 receptor activation has anxiogenic-like properties, but anxiety-related functions of CRF2 receptors remain unclear. The present study determined the effects of intracerebroventricular administration of a CRF2 agonist, urocortin 3, on behavior of male Wistar rats in the shock-probe, social interacti...

BACKGROUND AND PURPOSE Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused on incidence rather than outcome. The goal of this study was to determine the effects of prior exposure to chronic stress on ischemia-induced neuronal death, microglial activation, and anxiety-like behavior. METHODS In Experiment 1, mice were exposed to...

Background and Purpose—Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused on incidence rather than outcome. The goal of this study was to determine the effects of prior exposure to chronic stress on ischemia-induced neuronal death, microglial activation, and anxiety-like behavior. Methods—In Experiment 1, mice were exposed to 3...

To date, the relation between anxiety and risky behavior engagement among adolescents is unclear. While some research has shown a positive association, other research has indicated that anxious symptoms and such engagement are inversely related. In the current multi-wave, longitudinal study, the prospective relationship between stress, anxiety symptom clusters, and risky behavior engagement is ...

The present study examined children at risk for anxiety, analyzing their symptoms, selfesteem, and their perception of parental behavior. Data were collected as part of a large anxiety prevention study conducted at the University of Rhode Island. Elementary and middle school children who were identified as at risk for anxiety through an initial assessment were administered a battery of question...

No comprehensive metabolic profile of trait anxiety is to date available. To identify metabolic biosignatures for different anxiety states, we compared mice selectively inbred for ∼ 40 generations for high (HAB), normal (NAB) or low (LAB) anxiety-related behavior. Using a mass spectrometry-based targeted metabolomics approach, we quantified the levels of 257 unique metabolites in the cingulate ...

Objective(s): Our previous studies have shown that MgO nanoparticles (MgO NPs) could improve anxiety and reduce pain in animals. In this study, the effect of co administration MgO NPs and vitamin C on anxiety like behavior and nociception in postpartum depression (PPD) model were investigated.Materials and Methods:  Female mice (27 ± 3 g) were divided into groups: two control groups, PPD groups...