The energy dependence of intracellular protein breakdown has been recognized for a long time (1,2), but its biochemical mechanisms have begun to be elucidated only recently. This has been initiated by the establishment of several cell-free systems in which protein breakdown is stimulated by ATP (37 ) . We have found previously that the ATP-dependent proteolytic system from reticulocytes is comp...

A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A s...

The goal of this prospective longitudinal study was to determine the serological profile of early rheumatoid arthritis (RA), and to test whether antikeratin antibody (AKA), antiperinuclear factor (APF), anti-RA33 antibody and antinuclear antibodies (ANA) had an additional diagnostic value when prescribed after rheumatoid factor (RF)-detecting methods. Sixty-nine patients with early polyarthriti...

It is demonstrated here that cultured fibroblasts release into their medium a nondialyzable, protease-sensitive factor(s) capable of promoting the adhesion and spreading of virus-transformed rat fibroblasts on a plastic substratum. A relatively sensitive biological assay is described for quantitation of the adhesion-promoting factor (APF) activity in serum-free, conditioned medium harvested fro...

The aim of this in vitro study was to evaluate the shear bond strength of brackets after pre-treatment with different fluoride solutions. This study used 48 freshly extracted sound bovine incisors that were randomly assigned to 4 experimental groups (n=12). CG: (control) without treatment; NF: 4 min application of neutral fluoride; APF: application of 1.23% acidulated phosphate fluoride (APF) f...

One of the most important drawbacks of the three phases five-level NPC (Neutral Point Clamped) Active Power Filter (APF) is the neutral point balance. As the consequence, the capacitors voltages of the input DC bus of the APF are not equal which constitutes the major limitation for the use of this power converter. In order to stabilize these DC voltages, it is proposed in this paper to study th...

Glycopeptides are a class of molecules that comprise two distinct families of biologically important scaffolds, peptides and oligosaccharides, each playing important roles in cellular communication and signaling. Rarely are small, endogenous secreted glycopeptides found that have significant impact on the progression of a specific disease state, but such is the case for the antiproliferative fa...

objective: probable effect of fluoride containing materials like apf on sealants is very important. the purpose of this study is to assess the effect of frequent application of apf (1.23%) on the surface microhardness of two fissure sealants and one flowable composite.   methods: in this experimental study, 81 specimens of two fissure sealants and one flowable composite were prepared, using spe...

The American Psychological Foundation (APF) Charles L. Brewer Award for Distinguished Teaching of Psychology recognizes an outstanding career contribution to the teaching of psychology. The 2011 recipient of the Distinguished Teaching Award is Neil Lutsky. Dorothy W. Cantor, president of the APF, will present the APF Distinguished Teaching Award at the 119th Annual Convention of the American Ps...