Various abnormalities of lymphokine production have been described in patients with aplastic anemia. To determine if abnormal production of hematopoietic growth factors could contribute to the process of aplastic anemia we studied the in vitro production of human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) by phytohemagglutinin (PHA)- and antithymocyte glo...

Although aplastic anemia and myelodysplasia have been extensively investigated, little is known about their circulating cytokine patterns. We compared plasma soluble cytokines in 33 aplastic anemia, 57 myelodysplasia patients, and 48 healthy controls. High levels of thrombopoietin and granulocyte colony-stimulating factor, with low levels of CD40 ligand, chemokine (C-X-C motif) ligand 5, chemok...

Severe aplastic anemia is almost always fatal unless treated. Invasive fungal infections, particularly those caused by Aspergillus species, have long been recognized as a major cause of death in severe aplastic anemia. However, there are few specific reports about infections and their therapy in patients with aplastic anemia. Despite improvements in the last few years, the response rate of new ...

T HE OCCURENCE of impaired marrow function in paroxysmal nocturnal hemoglobinuria (PNH) has long been recognized. A smaller group of patients, with an initial diagnosis of aplastic anemia, have been noted to develop signs of PNH during the course of their illness.1 Such persons have been said to have “the aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome.”2 Also evident, in some case...

BACKGROUND Aplastic anemia is a rare and severe disease. Its incidence varies considerably worldwide. We aimed at describing the epidemiology of this disease, including the incidence, mortality and survival trends, in a well-defined population. DESIGN AND METHODS Since 1980, a case-control surveillance study of aplastic anemia has been carried out by a cooperative group, in the metropolitan a...

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Background: Bone marrow failure that results in pancytopenia causes aplastic anemia clinically. Aim: To determine the frequency of positive microRNAs plasma patients with anemia. Study Design: Descriptive cross-sectional study. Methodology: Aplastic were assessed for level and considered if was ≥2 Results: Majority 20(66.7%) aged ≤30 years only 10(33.3%) above 30 years. There 22(73.3%) male 8(2...

We carried out chromosomal analysis of a 33-year-old male who was diagnosed as having aplastic anemia. The patient showed severe pancytopenia, a normal NAP score, hypoplastic marrow and no myelodysplastic changes. 45,XO was found in all bone marrow cells examined, and in 10% of peripheral blood cells examined. To our knowledge, this is the first reported case of male aplastic anemia to show los...

P ROGNOSIS in aplastic anemia has improved since the introduction of testosterone therapy.1 This androgenic hormone has proved very useful in the treatment of children with congenital and acquired aplastic anemia,1-5 but appears to be less effective in adults with the same disorder.#{176} Oxymetho1one79 and other related steroids4’1015 have recently been used in place of testosterone with good ...

CONTEXT The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CAS...