Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has joined the ranks of 'superbugs' due to its enormous capacity to engender resistance. It demonstrates decreased susceptibility to most antibiotics due to low outer membrane permeability coupled to adaptive mechanisms and can readily achieve clinical resistance. Newer research, using mutant library screens, mic...

Free radicals and other oxygenor nitrogen-derived reactive species formed during cellular metabolism and respiration, like superoxide (O2 ), hydrogen peroxide (H2O2), and nitric oxide (NO), are important second messengers and fundamental mediators in biological processes, redox signaling, and cellular growth. However, over the past 2 decades it has become clear that reactive oxygen species (ROS...

REGIONAL anesthesia has evolved in recent years from a technique into an art, practiced by some pioneering anesthesiologists. As with any art form, regional anesthesia has obtained a level of complexity not seen before. Until recently, regional anesthesia was used by a select group, using sophisticated wording and techniques that prohibited its widespread implementation. However, with the devel...

Many information systems are reengineered and redeveloped in practice, since they are legacy software. Typically, no requirements and design specifications exist and, therefore, also no traceability information. While especially the long-term utility of such information is well known, an important question in reengineering is whether installing it can have immediate benefits in the course of th...

Prehistoric archaeological sites in the center of the Iranian Plateau suddenly disappeared around the end of the 4th millennium BCE. At Tepe Sialk, near Kashan, the last cultural period, namely Sialk IV - probably established around 3400 BCE after the last settlements of Sialk III6-7b - was abandoned approximately after 500 years. The material culture of this period, known as Proto-Elamite peri...