Aprotinin concentrations such as occur in vivo after intravenous injection of 100,000 KIU, inhibit ChE activity by about 5-16 per cent. The degree of inhibition is greatest between 6 and 20 minutes post-injection and is negligible after 30 minutes. When the ChE baseline activity is normal, 5-16 per cent inhibition does not lead to a prolongation of the action of suxamethonium. A prolongation of...

OBJECTIVE To evaluate if the hemostatic high-dose aprotinin seems to reduce the inflammatory process after extracorporeal circulation (ECC) in children. METHODS A prospective randomized study was conducted on children aged 30 days to 4 years submitted to correction of acyanogenic congenital heart disease with ECC and divided into two groups: Control (n=9) and Aprotinin (n=10). In the Aprotini...

Objective: Effects of aprotinin in off-pump coronary artery bypass (OPCAB) surgery have not yet been described. This study analyses hemostasiologic changes and potential benefit in OPCAB patients treated with aprotinin. Methods: In a prospective, double-blind, randomized study 47 patients undergoing OPCAB surgery were investigated. Patients received either aprotinin (2 £ 10 KIU loading dose and...

Human plasma kallikrein, a product of contact-activated plasma proteolysis, is moderately inhibited by aprotinin, a small polypeptide from bovine lung that has been used as an experimental drug in human disease states. Aprotinin has a Lys residue in the P1 (reactive center) position occupying residue 15. Since kallikrein is an arginine-directed serine protease, we hypothesized that an altered f...

of a thesis at the University of Miami. Thesis supervised by Professor Herman Cheung. No. of pages in text 62 The purpose of this study was to develop a fibrin gel system capable of serving as a three dimensional scaffold for the chondrogenesis of rabbit bone marrow mesenchymal stem cells (BM-MSCs) and to examine the effect of two fibrinolytic inhibitors, aprotinin and aminohexanoic acid, on th...

Aprotinin is a 6512-dalton bovine peptide antifi brinolytic agent. Due to its inhibitory effect on proteolytic enzymes (trypsin, plasmin, kallikrein), it is used to reduce blood loss and transfusion requirements and to limit the systemic infl ammatory response in major surgery under extracorporeal circulation (cardiac surgery, lung and liver transplantation, hip replacement). The frequency of a...

BACKGROUND Though multiple studies have affirmed the effectiveness of aprotinin in reducing blood loss in adult cardiac surgery, the possible benefit in pediatric cardiac surgery is controversial. METHODS In a double-blind, randomized, and placebo-controlled study, the efficacy of aprotinin in attenuating the hemostatic and inflammatory activation during cardiopulmonary bypass in 60 patients ...

Brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and N-terminal ANP are good research indices of the severity of heart failure. The stability of these peptides at room temperature has become an important factor in assessing their use as indicators of cardiac function in routine clinical practice. Inhibitors such as aprotinin are routinely added in the blood collection process, ...

conclusions in intervertebral herniated disc surgery, aprotinin and controlled hypotension treatments yielded similar results in terms of reducing blood loss and surgeon satisfaction with the field of operation. results 70 patients were identical in terms of demographics and the length of surgery. the two groups were not statistically different in terms of mean change in systolic, diastolic and...