Human erythrocytes have been used as a model for evaluating the chemical carcinogen-plasma membrane interaction. The carcinogenic aromatic amines 2-acetylaminofluorene, dimethylaminoazobenzene, and 3'-methyldimethylaminoazobene stabilize erythrocytes against lysis in hypotonic solution. In general, the stabilization potential of these compounds reflects their oil:water partition coefficients an...

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

Aromatic amines represent one of the most important classes of industrial and environmental chemicals: many of them have been reported to be powerful carcinogens and mutagens, and/or hemotoxicants. Their toxicity has been studied also with quantitative structure-activity relationship (QSAR) methods: these studies are potentially suitable for investigating mechanisms of action and for estimating...

Cation-pi bonds and amino-aromatic interactions are known to be important contributors to protein architecture and stability, and their role in ligand-protein interactions has also been reported. Many biologically active amines contain substituted ammonium moieties, and cation-pi bonding and amino-aromatic interactions often enable these molecules to associate with proteins. The role of organic...

Eight different zirconium phenoxyimine complexes were synthesized, characterized and tested as catalysts for ethylene polymerization. The phenoxyimine compounds were prepared by condensation of substituted salicylaldehydes with aliphatic and aromatic amines, the substituted salicylaldehydes from ortho substituted phenols and paraformaldehyde. The introduction of iodo substituents was achieved e...

Golka and colleagues (1) critically refer to our observation that NAT2 genotype had no impact on bladder cancer risk (2). We were able to demonstrate in our case–control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) that occupational exposure to aromatic amines and polycyclic aromatic amines was associated with an increased bladder cancer risk. On the b...

Nuruerous aromatic iii roe rirpounds are reduced to aromatic amines by nianrmalian liver. Bouts and Brodie (1) reported that the nitroreductase was localized in 0•,0(10 x g supernatant of liver. Although both N:A1)PH and NAUH can serve as electron donors, NADPH was about four times more effective:than NADH. I t is known that hydroxylamines are formed as intermediate in the reduction of nitrocom...

UNLABELLED BACKGROUND Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation. RESULTS Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrof...

Carbon-doped silica-supported NiCu quantitatively catalyzes nitroarenes to aromatic amines with ultra-high TOFs and was recyclable due the excellent anti-oxidation ability.