Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based m...

The abundance of arsenic-tolerant diazotrophic bacteria was compared in a long-term contaminated soil versus a non-contaminated one. In addition, the characterization of tolerant diazotrophic bacteria was carried out. Differences in the number of heterotrophic N2 fixers were found between soils. Contaminated soil showed a decrease in the microbial population size of about 80%, confirming the gr...

background one of the most common nasocomial bacteria is methicillin resistant staphylococcus aureus (mrsa). today, herbal extracts like zataria multiflora from the lamiaceae family are increasingly used. objectives in this study, the antibacterial effect of z. multiflora on 75 strains of was evaluated. materials and methods the strains of staphylococcus aureus were examined for isolation of st...

objective the extensive pollution of natural ecosystems has occurred by organophosphorus pesticides, being used for improvement of crop production in agriculture. biodegradation is interested in application of multifunctional bacteria containing genetical elements which specially degrade organophosphorus compounds. in this paper the detection of two bacteria species, pseudomonas and flavobacter...

Arsenic trioxide is used in clinical trials in the treatment of relapsed and resistant cases of acute promyelocytic leukemia. Adverse effects from arsenic in these studies have been multisystemic. Arsenic is known to cause corrected QT-interval prolongation and T-wave changes, but the potential for serious ventricular arrhythmias is less well understood. Torsades de pointes, a form of ventricul...

The pollution of the environment with toxic heavy metals is spreading throughout the world along with industrial progress. The present study deals with isolation, identification and characterization of heavy metal tolerant bacteria. Heavy metal tolerating bacteria was isolated from Mula river, Chinchwad, Pune, Maharashtra, India. On the basis of morphological, biochemical, 16S rDNA gene sequenc...

Inadvertent intake of inorganic arsenic and chromium through drinking water and food causing their toxic insults is a major health problem. Intestinal bacteria including Lactobacilli play important regulatory roles on intestinal homeostasis, and their loss is known to cause gastrointestinal (GI) disorders. Probiotic Lactobacilli resistance to arsenite and chromium-VI could be an importantfactor...

The bacterial community and genes involved in geobiocycling of arsenic (As) from sediment impacted by long-term gold mining were characterized through culture-based analysis of As-transforming bacteria and metagenomic studies of the arsC, arrA, and aioA genes. Sediment was collected from the historically gold mining impacted Mina stream, located in one of the world's largest mining regions know...