Retinoblastoma (RB) is an intraocular cancer that affects young children. There is an ongoing effort to find new agents for RB management that are effective, specific and with few side-effects. In the present study, we tested artesunate (ART), a synthetic derivative from the herbal drug artemisinin, used in the clinic for the treatment of malaria. We analyzed ART cytotoxicity in an RB cell line...

Air conditioning and refrigeration have become necessary in modern life, accounting for more than 7.8% of greenhouse gases (GHG) emitted globally. Reducing the environmental impact these systems is crucial meeting global GHG emission targets. Two principal directions must be considered to reduce air systems. Firstly, reducing direct effect by looking at less harmful refrigerants secondly, indir...

BACKGROUND Cigarette smoking has been associated with worse infertility treatment outcomes, yet some studies have found null or inconsistent results. METHODS We followed 225 couples who underwent 354 fresh non-donor assisted reproductive technology (ART) cycles between 2006 and 2014. Smoking history was self-reported at study entry. We evaluated the associations between smoking patterns and A...

BACKGROUND Assisted Reproductive Technology (ART) has undergone considerable changes over the last decade, with consequences on ART outcomes in different regions of the world being unknown. METHODS We conducted a systematic review of published national and regional ART registry data to assess how changes in clinical practice between 2004 and 2013 have impacted outcomes in Australia and New Ze...

in this paper, the effects of input temperature and compression ratio on the net output work and efficiency of the air standard cycles, i.e. atkinson cycle, diesel cycle and otto cycle are analyzed. we assumed that the compression and power processes are adiabatic and reversible and any convective, conductive and radiative heat transfer to cylinder wall during the heat rejection process may be ...

OBJECTIVE To compare cycle outcomes among normal-responding patients <or=30 years old receiving microdose follicular flare (MDF) and long-luteal agonist (LL). DESIGN Retrospective cohort study. SETTING Military-based assisted reproductive technology (ART) center. PATIENT(S) First autologous ART cycles among 499 women <or=30 years old from January 1999 to December 2005. INTERVENTION(S) A...

Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 ...

Advances in treating infertile couples by assisted reproductive technologies (ART) over more than three decades have greatly improved the chances of better outcomes. While twinning and higher order multiple birth rates are still high in most countries, lower rates have sometimes been achieved by single-embryo transfer. Multiple preg- Abstracts of the 12th Royan International Congress on Reprodu...

BACKGROUND Sperm chromatin structure is often impaired; mainly due to oxidative damage. Antioxidant treatments do not consistently produce fertility improvements and, when given at high doses, they might block essential oxidative processes such as chromatin compaction. This study was intended to assess the effect on male sub-fertility of a pure one carbon cycle nutritional support without stron...