BACKGROUND Cardiovascular mortality is high in hemodialysis (HD) patients. Early arterial pressure wave reflections predict mortality in HD patients, and HD acutely improves the central pressure waveform. Potassium (K) plays a crucial role in cardiac electrophysiology, and patients with end-stage kidney disease depend on HD for neutral K balance. We aimed to study the impact of dialysate K conc...

The brachial artery pressure waveform is abnormal in smokers, but the effect of smoking on the aortic pressure waveform in both smokers and nonsmokers, particularly in the younger population, is unknown. We compared the acute and chronic effects of smoking on large-artery properties in 185 healthy young smokers and nonsmokers (mean+/-SD, 22+/-5 years). We matched 41 chronic smokers for age, hei...

We developed a new technique to mathematically transform a peripheral artery pressure (PAP) waveform distorted by wave reflections into the physiologically more relevant aortic pressure (AP) waveform. First, a transfer function relating PAP to AP is defined in terms of the unknown parameters of a parallel tube model of pressure and flow in the arterial tree. The parameters are then estimated fr...

BACKGROUND Central systolic blood pressure (cSBP) has been postulated to correlate closely with cardiovascular risk. Identifying factors associated with cSBP is therefore important. Prolonged QT interval is known to be associated with cardiovascular outcomes and might also be associated with the arterial waveform and cSBP. We investigated the possible associations between electrocardiogram wave...

The purpose of this study is to build an automatic disease classification system using pulse waveform analysis, based on a Fuzzy C-means clustering algorithm. A self designed three-axis mechanism was used to detect the optimal site to accurately measure the pressure pulse waveform (PPW). Considering the artery as a cylinder, the sensor should detect the PPW with the lowest possible distortion a...

BACKGROUND Arterial pressure waveforms contain important diagnostic and physiological information since their contour depends on a healthy cardiovascular system 1. A sensor was placed at the measured artery and some contact pressure was used to measure the pressure waveform. However, where is the location of the sensor just about enough to detect a complete pressure waveform for the diagnosis? ...

40 Cardiac output measurement from arterial pressure waveforms presumes a defined relationship 41 between the arterial pulse pressure (PP), vascular compliance (C) and resistance (R). Cardiac 42 output estimates degrade if these assumptions are incorrect. We hypothesized that sepsis would 43 differentially alter central and peripheral vasomotor tone decoupling the usual pressure wave 44 propaga...

A method for estimation of central arterial pressure based on linear one-dimensional wave propagation theory is presented in this paper. The equations are applied to a distributed model of the arterial tree, truncated by three-element windkessels. To reflect individual differences in the properties of the arterial trees, we pose a minimization problem from which individual parameters are identi...

Objectives To test the usefulness of continuous assessment of arterial load based on a 3-element Windkessel model by a combined analysis of the esophageal Doppler derived-blood flow and arterial pressure waveform, against standard frequency-domain analysis of arterial impedance. Methods Time-domain variables of arterial impedance were obtained by the simultaneous analysis of the Doppler derived...