PURPOSE The present study was aimed at investigating L-asparaginase (L-ASE) activity (in plasma) and L-asparagine (L-ASN) depletion (in plasma and CSF) in children with newly diagnosed acute lymphoblastic leukemia (ALL) exposed for the first time to different L-ASE products. PATIENTS AND METHODS During the induction treatment of the AIEOP ALL 95 study, 62 patients were treated with either Erw...

BACKGROUND Plants rich in flavonoids, such as açaí (Euterpe oleraceae Mart.), can induce antinociception in experimental animals. Here, we tested an extract obtained from the stones of açaí fruits (açaí stone extract, ASE), a native plant from the Amazon region of Brazil, in models of acute/inflammatory and chronic pain. METHODS Antinociceptive effects of ASE were evaluated in the hot plate, ...

Polymorphism in cis-regulatory sequences can lead to different levels of expression for the two alleles of a gene, providing a starting point for the evolution of gene expression. Little is known about the genome-wide abundance of genetic variation in gene regulation in natural populations but analysis of allele-specific expression (ASE) provides a means for investigating such variation. We per...

We previously reported a rare germline variant (c.1-6531) that resulted in allele-specific expression (ASE) of death-associated protein kinase 1 (DAPK1) and predisposition to chronic lymphocytic leukemia (CLL). We investigated a cohort of CLL patients lacking this mutation for the presence of ASE of DAPK1. We developed a novel strategy that combines single-nucleotide primer extension (SNuPE) wi...

Vitamin D deficiency could cause insulin resistance. However, the underlying mechanisms are unclear. The 1α-Hydroxylase ["1α(OH)ase"] is a key enzyme for activate vitamin D3 synthesis. Here, we show that 1α(OH)ase stable knockdown by targeted shRNA led to vitamin D3 depletion in L02 hepatocytes. 1α(OH)ase silence also inhibited insulin-induced downstream signaling (IRS-1, ERK and AKT) transduct...

We describe artificial subtle expressions (ASEs) as an intuitive notification methodology for artifacts’ internal states for users. We prepared two types of audio ASEs: one was a flat artificial sound (flat ASE), and the other was a sound that decreased in pitch (decreasing ASE). These two ASEs were played after a robot made a suggestion to the users. Specifically, we expected that the decreasi...

IntroductIon Polyphenols are a large family of metabolic compounds that occur naturally in a wide variety of plant foods. Recently, polyphenols have attracted a great deal of attention due to their roles as natural antioxidants. Antioxidants are believed to provide a protective effect against oxidative damage diseases such as cancer, coronary heart disease, and stroke. It has been estimated tha...

Reducing cost and time required to build high quality software is a major goal for software developers. Building tools and techniques that can help achieve such a goal is the chief aim for Automated Software Engineering (ASE) researchers. However, in order to be effective an ASE researcher or professional must understand the characteristics of both successful and not-so-successful ASE tools, an...

BACKGROUND European trans-national adolescent smoking prevention interventions based on social influences approaches have had limited success. The attitudes-social influences-efficacy (ASE) model is a social cognition model that states smoking behaviour is determined by smoking intention which, in turn, is predicted by seven ASE determinants; disadvantages, advantages, social acceptance, social...

The lack of personal particulate matter (PM) monitoring technique hinders the knowledge negative health impacts caused by inhaling PM. Acoustophoresis has a potential to produce miniature particle sorters that can be carried inside human’s breath zone. Micron particles manipulated Acoustic Radiation Force (ARF), but sub-micron hardly directed due Streaming Effect (ASE). purpose this study is ex...