Serial exercise tests were carried out by 12 children with asthma on two study days. After a control exercise test either nedocromil sodium 4 mg or placebo were given double blind by metered dose inhaler. Highly significant inhibition of exercise induced asthma occurred after nedocromil, lasting for over two hours.

Exercise-induced bronchoconstriction (EIB) is the term used to describe the transient narrowing of the lower airways that follows vigorous exercise.1,2 Although EIB most commonly occurs in individuals with clinically recognized asthma, this condition is also reported in school children, armed forces recruits and elite athletes without asthma. Patients typically present with respiratory symptoms...

We have tested the effect of a porous cellulose fabric face mask. Nine asthmatic patients, anamnestically sensitive to cold, took part in exercise tests on an ergometer bicycle at a temperature of approximately -10 degrees C, with and without a face mask. For comparison, exercise tests were also performed with breathing taking place through a woolen scarf. Three minutes after finishing the exer...

The prevalence of asthma seems to be on the increase and risk factors are not well-established. To investigate the relationship between asymptomatic increased bronchial responsiveness to exercise (BRE) and subsequent development of asthma, we studied a population sample of children and adolescents, aged 7-17 yrs at enrollment, examined twice 6 yrs apart (54 and 68%, respectively, of the origina...

BACKGROUND Bronchial hyperreactivity to methacholine is present in children with asthma and other types of paediatric chronic obstructive pulmonary disease (COPD), while hyperreactivity to exercise is more specific for asthma. Adenosine 5'-monophosphate (AMP) is a potent bronchoconstrictor and, like exercise, may provoke asthma by activating mast cells. This study investigated the suitability o...

BACKGROUND Aerobic exercise appears to have clinical benefits for many asthmatics, yet a complete understanding of the mechanisms underlying these benefits has not been elucidated at this time. PURPOSE The objective of this study was to determine feasibility for a larger, future study that will define the effect of aerobic exercise on cellular, molecular, and functional measures in adults wit...

Clinical asthma is estimated to occur in 4 to 7 percent of the US population, but respiratory symptoms are much more common. The correlation between asthma, tests of bronchial hyperresponsiveness, and symptoms is imprecise and difficult to ascertain. The prevalence of exercise-induced airflow obstruction is not well known in healthy adults. We studied 100 consecutive US Air Force members to det...