this study was undertaken in order to ascertain the carrier rate of group a hemolytic streptococci in the throats of pupils in selected schools of tehran, and to evaluate the role of socio-economical factors on carrier state. during the period of six months, 7020 children and adolescents, aged 10 to 17, were studied. these pupils were visited at their schools and their socio-economical level wa...

The clinical severity of common hereditary elliptocytosis (HE) is highly variable, ranging from an asymptomatic carrier state to a severe hemolytic anemia. To elucidate the molecular basis of this variable clinical expression, we evaluated 56 subjects from 24 HE kindred, who carry alpha spectrin mutants characterized by a spectrin dimer (SpD) self-association defect related to a structural abno...

OBJECTIVE To determine whether there is a greater prevalence of asymptomatic first-degree relatives (FDR) of patients with progressive supranuclear palsy (PSP) performing abnormally on the PD test battery (PD Battery) compared to sex- and age-matched normal control (NC) individuals. The PD Battery incorporates tests of motor function, olfaction, and mood. It has high specificity and sensitivity...

Relatively little attention appears to have been paid to the male gonorrhoea " carrier" (a man with the disease, and capable of transmitting it, but with no symptoms, or with symptoms so slight as to be ignored), although such cases were well known to develop after inadequate sulphonamide treatment. There is little evidence that treatment with penicillin, even in small doses, ever produces a ca...